It took only a decade to go from mice to rats!
"In the past decade, methods have been developed to generate germ cells from pluripotent stem cells for studies of development and in vitro gametogenesis. However, offspring from in vitro–derived germ cells has only been achieved in mice. ...
Now, rats join the club. A study published today (April 7) in Science reports that researchers have produced healthy, fertile rat offspring with sperm made from stem cells. ..."
Now, rats join the club. A study published today (April 7) in Science reports that researchers have produced healthy, fertile rat offspring with sperm made from stem cells. ..."
From the abstract:
"The in vitro generation of germ cells from pluripotent stem cells (PSCs) can have a substantial effect on future reproductive medicine and animal breeding. A decade ago, in vitro gametogenesis was established in the mouse. However, induction of primordial germ cell–like cells (PGCLCs) to produce gametes has not been achieved in any other species. Here, we demonstrate the induction of functional PGCLCs from rat PSCs. We show that epiblast-like cells in floating aggregates form rat PGCLCs. The gonadal somatic cells support maturation and epigenetic reprogramming of the PGCLCs. When rat PGCLCs are transplanted into the seminiferous tubules of germline-less rats, functional spermatids—that is, those capable of siring viable offspring—are generated. ..."
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