Common Sense
In honor of Thomas Paine and other Founders & Immigrants. In memory of my daddy Horst Bingel and my mom Irma Bingel
Friday, March 27, 2026
In a rare event, the moon got a massive new crater and ejecta found up to 120 km from crater
Trump, Xi, and the Specter of 1914 | Foreign Affairs. Really!
Are Waymos driving significantly longer than humans to get to a destination?
Polar algae contain hundreds of genes given to them by giant viruses—roughly 5% of their genome
An Iranian missile struck a Saudi Arabian air base, damaging several U.S. refueling aircraft
Ukrainian drones hit all three Baltic States this week − did Russia redirect them?
Unified theory explains paradox of freezing water water thrown into air to make snow
Iranian hackers backed by the Iranian government claim breach of FBI director Kash Patel's personal email account
Waymo’s skyrocketing ridership in one chart
Scientists uncover two million ancient DNA switches controlling plant genes
Olympics Bar Biological Males from Women’s Events
Kinder sollen keine Pornografie schauen: Die EU verlangt von Portalen wie Pornhub eine wasserdichte Altersverifizierung
Was für ein Unsinn! Ist das ist ein Vorwand/Versuch Pornographie wider zu verbannen?
Warum können das z.B. die Eltern und die Smartphone/Netzwerk Betreiber nicht verhindern?
"In Mitgliedsländern der EU schauen bis zur Hälfte der über 12-Jährigen Pornos auf dem Smartphone. Schuld daran seien die nachlässigen Videoportale, sagt die Kommission." (Quelle)
Unprecedented footage shows sperm whales joining forces to help a newborn calf
IDF soldiers target Hamas infrastructure, kill over 60 terrorists in past month
Thursday, March 26, 2026
Google caches in with TurboQuant extreme compression
How Autonomous Drone Warfare Is Emerging in the Ukraine
Is the current British Defense Secretary John Healey a fool?
Defence Secretary John Healey ... ‘We all know somebody who’s had their phone stolen,’ he told Sky News. ‘We’re not all the chief-of-staff of the Prime Minister,’ replied Sophy Ridge. Yet the question isn’t simply whether the phone was stolen, but the cascade of inexplicable behaviour that followed.
A new clue to how the skin detects physical touch
PIEZO1 responds to diverse stimuli including membrane stretch2 and shear stress, whereas
Here we combine single-molecule MINFLUX fluorescence nanoscopy with electrophysiology to link the conformational states of PIEZO2 to channel gating in intact cells. We find that PIEZO2 is intrinsically more rigid than PIEZO1, and that disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.
Tiny bubbles, sound waves clean produce safely and effectively
We identify and characterize a distinct translational resonance of these bubbles, occurring at significantly lower frequencies (e.g., 50 Hz for 1.3 mm diameter bubbles) than the Minnaert resonance for a bubble of the same size. At this translational resonance, stationary bubbles exhibit amplified lateral swaying, while bubbles sliding on an inclined surface display pronounced “stop-and-go” dynamics.
The theoretical model treats the bubble as a forced, damped harmonic oscillator. In this framework, surface tension supplies the restoring force, while the inertia is governed primarily by the hydrodynamic added mass of the surrounding fluid. It accurately predicts the observed resonant frequency scaling with bubble equilibrium radius R0 (∝R0−3/2).
Cleaning efficacy, assessed using protein-based artificial soil on glass slides, was significantly improved when bubbles were driven at their translational resonant frequency compared to off-resonant frequencies or nonacoustic conditions. These findings demonstrate that leveraging translational resonance enhances bubble-induced shear and agitation, offering an effective and sustainable mechanism for surface cleaning."
What's for dinner? Tooth enamel reveals what early Mesopotamians really ate
For several years China mapped ocean floors as it prepares for submarine warfare with US
Brightpick Launches Gridpicker; Highest-Throughput Robotic Fulfillment System Ever Developed
VW in talks with Rafael to produce Iron Dome in a German VW car plant - report
Irre Einmischung: Bundespräsident Steinmeier belehrt die Bundesregierung zum Iran und greift die USA öffentlich massiv an
Weltrekord in Bahia: Nexat erntet 637 t Soja in 8 Stunden
So sieht die FDP heute aus
Die Partei wurde gründlich geschoren, zu recht! Ausser Show nichts gewesen in den etwa letzten 20 Jahren oder so!
FDP Generalsekretärin Nicole Büttner hat sich nach einer verlorenen Wahlwette den Kopf scheren lassen. Source
How huntingtin proteins travel in the brain
Amazing stuff!
"Mutant huntingtin protein, which causes the neurodegenerative disorder Huntington’s disease, travels through the brain using tiny ‘tunneling nanotubes’, research has revealed. Researchers found that a protein called Rhes binds with a protein for cellular acidity regulation, SLC4A7, to build tube-like structures creating a highway to shuttle huntingtin from neuron to neuron. Interrupting this pathway minimised the spread of huntingtin in the brain and offers a potential druggable target."
From the abstract:
"Tunneling nanotubes (TNTs) are membranous structures that mediate intercellular transfer of proteins, including the pathogenic mutant Huntingtin (mHTT) protein in Huntington disease (HD).
We previously identified the ras homolog enriched in the striatum (Rhes) as a key regulator of TNT formation and mHTT transmission; however, the molecular components underlying this process remained unknown.
Here, using unbiased liquid chromatography–tandem mass spectrometry analysis of membrane-associated Rhes complexes, we identify Slc4a7 (solute carrier family 4 member 7), an intracellular pH sensor, as a top membrane-binding partner of Rhes.
Functional studies revealed that small interfering RNA–mediated depletion or pharmacological inhibition of Slc4a7 substantially reduced Rhes-induced TNT formation and suppressed mHTT intercellular transfer.
Mechanistically, Rhes directly interacts with Slc4a7 through both its amino- and carboxyl-terminal domains and modulates intracellular pH to facilitate TNT formation. This interaction does not depend on the transporter activity of Slc4a7. However, inhibition of Rhes farnesylation—a lipid modification that anchors Rhes to the membrane—disrupts its binding to Slc4a7 and abolishes TNT formation.
Slc4a7 knock-out mice showed markedly reduced cell-to-cell transmission of mHTT in the striatum in vivo.
Together, these findings uncover a previously unrecognized Rhes-Slc4a7 signaling axis critical for TNT-mediated mHTT transmission and highlight Slc4a7 as a potential therapeutic target to limit disease spread in HD."
Targeting Tunneling Nanotubes Reduces Spread of Mutant Huntington’s Protein
Membrane-associated Rhes-Slc4a7 complex orchestrates tunneling nanotube formation and mutant Huntingtin spread (open access)
Fig. 1. Membrane-anchored Rhes drives the formation of TNTs between cells.
Past greenhouse gas emissions will cost global economy trillions | Stanford Report. Really!
- Researchers developed a new framework for calculating “loss and damage,” or harms from climate change that countries can’t prevent by cutting emissions or avoid through adaptation.
- U.S. emissions since 1990 have caused more than $10 trillion in global economic damages, with roughly a third of the damage hitting the country’s own GDP.
- Removing carbon dioxide from the atmosphere is a potential alternative to compensation for damages caused, but becomes much less effective if action is delayed [???].
Chart of the day
Researchers have found that intravenous administration of a nonpathogenic virus, oncolytic alphavirus M1 (OVM), suppresses the growth of glioblastoma, a lethal brain cancer, and also reverses the cancer’s suppression of the immune system. OVM triggers an immune response to cell death (ICD), restoration of the immune system, tumour microenvironment (TME) reprogramming and proliferation of immune cells that specifically target the tumour. (Source)
Suspended Massachusetts female cop arrested on child rape charges, held on $10K bail
Plate tectonics is even older than we thought
It also facilitates efficient planetary heat loss, thereby maintaining convection in Earth’s core and the generation of a magnetic field. The presence of a magnetosphere—a space around Earth dominated by its magnetic field—provides shielding from solar and cosmic radiation and mediates the loss of atmospheric gas into space. Deciphering plate motions in Earth’s early history can thus hint at how the planet looked several billion years ago. On page 1278 of this issue, Brenner et al. (2) report differential plate motion 3.5 billion years (Ga) ago by recovering ancient magnetic field records from rocks in Australia. This may provide clues to the nature of early tectonic motions and their role in sustaining habitable conditions."
Japan to temporarily lift coal power plant curbs over Hormuz crisis
Disclaimer
I am currently blogging from behind the Great Firewall of China.
My Internet service in China is very spotty. Thus, I am not able to blog as usual.
Jury Rules Social Media Liable for Teen's long-term Addiction. Really!
I hope this ridiculous verdict will not stand! The rest of the world will have a good laugh again about American jurisprudence!
What about the parents of this child?
"Jury Rules Social Media Liable for Teen's Addiction
A Los Angeles jury ruled Wednesday that Meta and YouTube must pay a combined $6 million in damages to a 20-year-old woman who said the platforms hooked her as a child through design features like infinite scroll, autoplay, and algorithmically timed notifications.
The plaintiff, known as K.G.M., testified she began using YouTube at 6 and Instagram at 9, eventually spending 16 hours in a single day on Instagram, spiraling into depression, anxiety, and body dysmorphia.
Jurors targeted platform design itself as a defective product, a legal theory one tech policy professor compared to the tobacco lawsuits.
More than 1,500 similar suits against Meta, YouTube, Snapchat, and TikTok are pending in California courts alone."
Wednesday, March 25, 2026
Israeli strikes on a major Caspian Sea port in northern Iran last week targeted Russian support for Iran in the ongoing war
Cause for concern!
Was this a high stakes gamble to target Russia? Good, that Putin the Terrible is bogged down in the Russia-Ukraine War thanks to the very effective Ukrainian defense!
So far World War III (Russo-Ukrainian War by any other name) has been geographically very limited. Will this war expand to other geographical regions?
"... Israeli strikes on a major Caspian Sea port in northern Iran last week targeted Russian support for Iran in the ongoing war ... This report is consistent with CTP-ISW's previous reporting that the IDF struck a Caspian Sea port that Iran uses to trade both military and non-military goods with Russia. The IDF targeted “dozens” of vessels, a command center, and a shipyard at Bandar Anzali Port, Gilan Province, on March 18. The Israeli strike on the port followed reports that Russia has provided Iran with satellite imagery and Shahed drones since the war began. Israeli media reported on March 19 that the Israeli strikes in Bandar Anzali “shut down” a critical supply line between Iran and Russia for both basic goods, such as wheat imports, and military equipment.The Wall Street Journal added on March 24 that Russia uses the Caspian Sea to receive Iranian Shahed drones as well as artillery shells and other ammunition to resupply its troops on the front lines with Ukraine. More than 300,000 artillery shells and a million rounds of ammunition were shipped from Iran to Russia in 2023 via the Caspian Sea, according to unspecified documents seen by the Wall Street Journal."