Saturday, April 25, 2026

Meet GitNexus: An Open-Source MCP-Native Knowledge Graph Engine That Gives Claude Code and Cursor Full Codebase Structural Awareness

Recommendable!

"GitNexus is an open-source knowledge graph engine that indexes any codebase into a structured dependency map — capturing every function call, import, class inheritance, and execution flow using Tree-sitter AST parsing — and exposes it to AI coding agents like Claude Code, Cursor, Codex, OpenCode, and Windsurf via a Model Context Protocol (MCP) server. Instead of letting agents edit code blind and ship breaking changes, GitNexus pre-computes the entire dependency structure at index time so agents can answer architectural questions like "what depends on this function?" in a single query, with confidence-scored blast radius analysis, 360-degree symbol context, pre-commit impact detection, and coordinated multi-file renames — all triggered by one command: npx gitnexus analyze. Fully local, zero server, 13 languages supported, and already at 19,100 GitHub stars"

Meet GitNexus: An Open-Source MCP-Native Knowledge Graph Engine That Gives Claude Code and Cursor Full Codebase Structural Awareness - MarkTechPost

DeepSeek AI Releases DeepSeek-V4

Recommendable! Seems the latest DeepSeek model comes with several  interesting innovations!

"Key Takeaways
  • Hybrid CSA and HCA attention cuts KV cache to 10% of DeepSeek-V3.2 at 1M tokens.
  • Manifold-Constrained Hyper-Connections (mHC) replace residual connections for more stable deep layer training.
  • The Muon optimizer replaces AdamW for most parameters, delivering faster convergence and training stability.
  • Post-training uses On-Policy Distillation from 10+ domain experts instead of traditional mixed RL.
  • DeepSeek-V4-Flash-Base outperforms DeepSeek-V3.2-Base despite having 3x fewer activated parameters.
..."

Friday, April 24, 2026

US Defense Secretary Hegseth warns European allies to stop 'free riding' and help reopen the strait

Good news! Bravo!

During the Cold War, the European NATO members were accused like this many times!

After the Cold War it is perhaps time to dissolve the NATO. Let the Europeans build their own defense!

Hegseth warns European allies to stop 'free riding' and help reopen the strait (partially behind paywall)

China: Teeth ceaning at a dental clinic in Zhengzhou

What an experience!

You pay per natural tooth, crowns are not counted! I never encountered this before in my life.

Dental flossing not applied!

No mirror was provided at the end of service to review your cleaned teeth!

The ultrasonic scaler was applied extensively before and after polishing. Why?

There were two patient seats, two patients in the same small room with about six dental staff. 

Hidden mutations in immune cells linked to autoimmune disease

Good news! This could be a breakthrough!

"New research suggests that autoimmune diseases may be driven by DNA mutations in immune cells that remove the natural brakes on the immune system. It reveals a previously hidden role for somatic mutations — DNA changes acquired throughout life — in diseases beyond cancer.

Researchers ... used a series of cutting-edge techniques to identify previously unseen changes in DNA that may contribute to thyroid autoimmunity, where the immune system attacks the thyroid gland. ...

The researchers used several advanced DNA analysis techniques.
Firstly, they used a method called NanoSeq, which they recently developed and allows detection of rare mutations invisible to traditional DNA sequencing methods, to look for genetic changes that may drive the disease. They found that many B cells had developed inactivating mutations in key genes that normally control the immune system.

Next, using additional methods that look at the DNA of individual cells and microscopic areas of tissue, the researchers found that many B cells in each patient carried several mutations in key genes.
Two critical immune-checkpoint genes, TNFRSF14 and CD274 (or PDL1), were often lost independently in multiple clones of mutated B cells in each patient. Some of these clones had even acquired as many as six driver mutations over many years, silently building up changes in DNA before symptoms appeared, a highly unexpected observation outside of cancer.
Importantly, artificial inactivation of these genes, in experimental studies or during cancer immunotherapy, is known to cause thyroid autoimmunity. The researchers have now found frequent mutations in these genes occurring in autoimmune patients. ..."

From the abstract:
"Our immune system contains multiple checkpoints to prevent the activation of self-reactive lymphocytes. How some lymphocytes escape these constraints to cause autoimmune disease remains poorly understood. A long-standing hypothesis posits that somatic mutations in immune-regulatory genes may enable self-reactive lymphocytes to bypass tolerance checkpoints1–3, but testing this has been challenging due to technical limitations.
Here, we use whole-exome and targeted NanoSeq, an accurate single-molecule DNA sequencing protocol, to comprehensively search for driver mutations in autoimmune thyroid disease. This revealed many B cell clones convergently acquiring loss-of-function mutations in the key immune checkpoint genes TNFRSF14 (HVEM) and CD274 (PD-L1), as well as less frequent mutations in other immune genes.
In highly inflamed biopsies, we detected tens to hundreds of independent immune checkpoint mutant clones. Laser microdissection, methylation sequencing, spatial transcriptomics, immunostaining, single-nucleus DNA sequencing, and antibody synthesis localised these mutations to B cells, confirmed some to be self-reactive, and identified clones carrying multiple hits.
We found widespread TNFRSF14 biallelic loss, and clones with as many as 4-6 driver mutations. Whilst each clone accounts for a small fraction of cells (typically <1%), the myriad mutant clones in each donor amounted to a substantial fraction of B cells harbouring driver mutations.
Our results support the hypothesis that somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution, providing new insights into the molecular basis of autoimmune disease."

Hidden mutations in immune cells linked to autoimmune disease "Mutations in immune cells may be the missing piece in the autoimmune disease puzzle."

Academic freedom slides globally, as it takes a nosedive in the US. Really!

Let me guess, a case of Trump Derangement Syndrome by the Royal Society of Chemistry! What a piece of junk journalism!

"Academic freedom continues to decline globally, with a marked fall in the US, according to the 2026 update to the Academic Freedom Index. The index revealed that over the last decade academic freedom has slipped in 50 countries, with just nine registering improvement. ...

‘This academic freedom erosion is part of broader democratic backslide that we’re seeing in the US,’ [???] says Jennifer Jones, director of the Center for Science and Democracy at the Union of Concerned Scientists. ‘It mirrors the rise of authoritarianism that we’ve seen in Hungary and Turkey [???], where higher education is often targeted.’ ..."

Academic freedom slides globally, as it takes a nosedive in the US | News | Chemistry World

The Trump administration said it would allow executions by firing squad and restore the use of lethal injections in federal death-penalty cases

 As much as I hate capital punishment, but this is good news!

Apparently, the administration of the senile, demented and pathological liar 46th President tried to indirectly abolish the death penalty.

"The Justice Department said many of the limits the Biden administration put on carrying out federal death sentences would be removed. Until recently, firing squads were almost unheard of in modern executions. President Trump, in his first term, reactivated the federal death penalty after a 17-year hiatus and put 13 inmates to death in its final months. Since his return to office, the DOJ is seeking death sentences against 44 defendants."

Wall Street Journal What's news

A majority of health research focuses on men's bodies. Nonprofit FemTechAZ aims to change that. Really!

A case of junk journalism! I have seen at least one other, similar news report this week!

Feminists have been repeating this story since the 1960s or so!

Yes, for historical reasons medicine focused on male bodies in the past, but this is not true anymore for at least the past 50 years. It time to cancel this false, outdated  propaganda!

Caveat: I did not read the entire article.

A majority of health research focuses on men's bodies. Nonprofit FemTechAZ aims to change that

What is wrong with the Israel-Lebanon ceasefire?

A lot! I have been irritated by this so called cease fire agreement since it's inception!

Israel is not at war with Lebanon, but with the Iran sponsored Hezbollah terrorists operating from the territory of Lebanon!

Why was the Lebanese government incapable or unwilling to address the Islamist terrorism attacking Israel on its territory? A huge failure by the Lebanese government! Almost like a failed state!

Google Says 75% of the company's new Code Now Generated by AI

Amazing stuff! Good news! With the help of ML & AI we can now produce so much more programming code (in any programming language)!

"
  • Three-quarters of new code at Google is being generated by AI, the company said.
  • The number has been steadily increasing as the company pushes staff to adopt AI tools.
  • Google CEO Sundar Pichai said a recent code migration was done six times faster thanks to AI agents.
...

 As of October 2024, around a quarter of the company's code was AI-generated, Google said at the time.
Last fall, it said the number had risen to 50%. ..."

Google Says 75% of Fresh Code Now Generated by AI "Google announced this week that 75 percent of all new code created within the company is currently being generated by AI systems and subsequently reviewed by human engineers."

Plant seeds can actually sense the sound of rain

Amazing stuff! The sound of rain! Let it rain, let it rain!

"MIT engineers found that plant seeds can actually sense the sound of rain, with rice seeds germinating 30% to 40% faster when exposed to the vibrations of falling water droplets."

"... In experiments with rice seeds, the team found that the sound of falling droplets effectively shook the seeds out of a dormant state, stimulating them to germinate at a faster rate compared with seeds that were not exposed to the same sound vibrations. ..."

"... the first direct evidence that plant seeds and seedlings can sense sounds in nature. Their experiments involved rice seeds that they submerged in shallow water. Rice can germinate in both soil and shallow water. The researchers suspect that many similar seed types may also respond to the sound of rain. ...

They found that when a raindrop hits the surface of a puddle or the ground, it generates a sound wave that makes the surroundings vibrate, including any shallowly submerged seeds. These vibrations can be strong enough to dislodge a seed’s “statoliths,” which are tiny gravity-sensing organelles within certain cells of a seed. When these statoliths are jostled, their movement is a signal for seeds and seedlings to grow and sprout. ..."

From the abstract:
"The ability of natural environmental sound to stimulate seeds and seedlings sufficiently to foster growth has not been previously demonstrated or quantified.
To study this, rain sound is a logical starting point. Rain produces extremely high amplitude sound pressure with commensurate particle displacements in the upper soil, puddles and wetlands where many plant seeds germinate.
Experiments were conducted with controlled rain drops impacting soil and shallow water puddles containing submerged seeds of rice (oryza sativa). Germination rates were measured as the peak sound pressure of drop impact was varied. The displacements of micro-meter-scale statoliths relative to the structure of specialized seed cells that sense gravitational direction were estimated as a function of the controlled rain sound forcing.
The results here indicate rice and related seed types can sense the sound of rain impacting the soil or water surface above them and respond by accelerating germination at depths where impulsive rain sound is sufficiently intense to intermittently shake statoliths from contact with cell membrane receptors and trigger gravitropic growth mechanisms.
The ability to perceive rain sound and respond with accelerated germination is found to be roughly limited to the relatively shallow depths that are also beneficial to seedling survival."

Friday, April 24, 2026 - Join The Flyover


Plants can sense the sound of rain, a new study finds (original news release) "Experiments by MIT engineers show rice seeds sprout faster to the sound of rain."


Kakapel rock art timeline reveals 9,000 years of painters in Kenya

Amazing stuff! The abstract of this research paper is lousy and dilettante!

"A recent study ... presents the first millimeter-accurate recording of the paintings at Kakapel rock shelter in Kenya, linking the layers of rock art painted over thousands of years to at least three culturally and genetically distinct groups.

The combination of rock art analysis, aDNA, and excavation data makes Kakapel one of the most comprehensively understood rock art sites in eastern Africa. ..."

From the abstract:
"... first described the Kakapel rock art of western Kenya in 1977.  ...
Fieldwork in 2011 was undertaken to ... further research at the site. This paper presents the first millimetre-accurate redrawing of the main panel at Kakapel and places the site within the broader context of eastern African rock art to propose an age and authorship for the different painted traditions represented there.
It thus builds on and extends current understandings of the rock art sequence of eastern Africa."

Kakapel rock art timeline reveals 9,000 years of painters in Kenya



Figure 4. Kakapel: redrawing of the images in Layer 1 (redrawn by Wendy Voorveld in 2012 and coloured for publication by Kgolagano Vena).


Figure 5. Kakapel: redrawing of the images in Layer 2 (redrawn by Wendy Voorveld in 2012 and coloured for publication by Kgolagano Vena).


Figure 6. Kakapel: redrawing of the images in Layer 3 (redrawn by Wendy Voorveld in 2012 and coloured for publication by Kgolagano Vena).


Figure 1. Map of East Africa showing location of Kakapel rock art site in relation to other sites and places mentioned in the paper.



President Trump likes weed by reclassifying marijuana as a less dangerous drug

Good news! Bravo! Finally, this very long overdue correction has been made!

"Yes, since the passage of the Controlled Substances Act of 1970 (enacted in 1971), the U.S. federal government has classified cannabis as a Schedule I drug, placing it in the same category as heroin, LSD, and ecstasy" (Google AI)

"The Trump administration is reclassifying marijuana as a less dangerous drug.
The move marks a significant policy shift that could make it easier to buy and sell pot as well as reward cannabis-industry investors.
Weed has been classified the same way as LSD and heroin since 1970. The downgrade makes it possible to obtain the drug for medical reasons with a prescription; recreational use remains illegal under U.S. law. Doctors and researchers say marijuana can pose real risks to people’s health."

Former girls' high school basketball coach hit with 32 sex charges, including 'deviant sexual intercourse with a student'

Another Me Too event!

"Agrand jury on Tuesday indicted a former Alabama high school girls' basketball coach who's facing 32 sex crime charges in connection with accusations that she sexually abused a student, according to multiple reports.

Paige Adams — former girls' basketball coach at Cold Springs High School — was arrested Tuesday and booked into the Cullman County Jail, according to jail records. ..."

Former girls' high school basketball coach hit with 32 sex charges, including 'deviant sexual intercourse with a student' "The suspect's husband reportedly filed for divorce and asked for sole custody of the couple's child."




Disclaimer

Since end of February, I  am blogging from behind the Great Firewall of China.

My Internet service in China is very spotty. Thus, I am not able to blog as usual.

CATL claims 6-minute charge and 1,500km range for new electric vehicle batteries

 Good news!

"CATL has developed a battery capable of allowing an electric vehicle to drive 1,500km on a single charge, the Chinese group claimed on Tuesday, as it challenges BYD for supremacy on range and charging speed. ..."

CATL claims 6-minute charge and 1,500km range for new electric vehicle batteries "Chinese group also slashes charging time in race against BYD for electric vehicle battery supremacy"

Packaging artist: CATL announces Qilin EV battery with 1000 km range "The Chinese battery manufacturer CATL is introducing an advanced fast-charging CTP battery in Beijing for lighter cars with more space and range."


CATL's Qilin Battery is continuously being improved.



Democratic lesbian Latina running for US Congress is accused by 4 women of unwanted sexual advances

 Headline of the day! Welcome to the age of gender equality!

"A Latina lesbian member of the Salt Lake City Council has been accused by four people of sexual harassment while she mounts a campaign to win a U.S. congressional seat.

Three of the accusers are elected officials, and all said they were subjected to unwanted sexual advances from Eva Lopez Chavez. ..."

Democratic lesbian Latina running for Congress is accused by 4 women of unwanted sexual advances


Eva Lopez Chavez (Source)



Clearing Strait of Hormuz of mines could take 6 months, Pentagon tells Congress

Where are the Europeans when you need them??? Do some minesweeping!

Only 20 mines? It would take 6 months to remove them???

"... Three officials, speaking on the condition of anonymity because of the discussion’s sensitivity, said lawmakers were told that Iran may have emplaced 20 or more mines in and around the Strait of Hormuz, a vital waterway for the movement of Middle Eastern oil through the Persian Gulf. Some were floated remotely using GPS technology, which has made it difficult for U.S. forces to detect the mines as they are deployed, the senior defense official told lawmakers. Others are believed to have been laid by Iranian forces using small boats. ..."

Clearing Strait of Hormuz of mines could take 6 months, Pentagon tells Congress "The Pentagon assessment, shared in a classified briefing for lawmakers, suggests gasoline and oil prices could remain elevated through the midterm elections."

Thursday, April 23, 2026

Innovation von Bosch: „Das ist ein Meilenstein für das automatisierte Fahren“. Wirklich!

Ich habe meine Zweifel an dieser Meldung! Ist mir nicht bekannt, das Bosch auf dem Gebiet etwas vorzuzeigen hat.

Innovation von Bosch: „Das ist ein Meilenstein für das automatisierte Fahren“ (behind paywall) "Der weltgrößte Autozulieferer Bosch steckt in der Krise. Nun präsentiert der Hersteller einen Autopiloten mit KI-Software, der das Fahren revolutionieren soll. Losgehen soll es in China, in ein paar Jahren aber auch in Deutschland."




Wednesday, April 22, 2026

Will the quantum superposition of time soon be tested in a laboratory?

Amazing stuff! Food for thought! Can time run simultaneously faster and slower?

"Trapped ions are versatile platforms used for quantum computing and ultra-precise timekeeping. New results now show that combining these capabilities can reveal a deeper layer of physical reality: quantum superpositions of the passage of time. ...

Few concepts in physics are as familiar, yet as enigmatic, as time.
In Einstein’s theory of relativity, time is not absolute: its passage depends on motion and gravity.
But when combined with quantum physics, this relativistic form of time becomes even more counterintuitive. According to quantum theory, the flow of time itself may exist in a genuine quantum superposition, ticking faster and slower at the same time. ...

Now, a new paper titled Quantum signatures of proper time in optical ion clocks, published on April 20, 2026 in Physical Review Letters ... shows that this striking possibility may soon be tested in the laboratory. ...

In this work, a team ... explores quantum aspects of the flow of time and how they can be accessed with atomic clocks. Their results suggest that the same quantum technologies being developed for next-generation clocks and quantum computers may soon probe something far more fundamental: When a clock’s motion obeys quantum mechanics, its movement can exist in superposition, and with it the recorded passage of time itself.
This is analogous to Schrödinger’s famous thought experiment, where the counterintuitive nature of quantum superposition is illustrated by a cat being both alive and dead; here it is the passage of time itself that is in superposition, like a cat that is both young and old at once. ..."

From the abstract:
"Optical clocks based on atoms and ions probe relativistic effects with unprecedented sensitivity.
They resolve time dilation due to atom motion or different positions in the gravitational potential through frequency shifts. However, all measurements of time dilation so far can be explained effectively as the result of dynamics with respect to a classical proper time parameter.
Here we show that atomic clocks can probe effects where a classical description of the proper time dynamics is insufficient as superpositions of proper time emerge.
We apply a Hamiltonian formalism to derive time dilation effects in harmonically trapped clock atoms and show how second-order Doppler shifts due to the vacuum energy, squeezing, and quantum corrections to the dynamics arise.
We also demonstrate that time-dilation-induced entanglement between motion and clock evolution can become observable in state-of-the-art clocks when the motion of the atoms is strongly squeezed, realizing proper time interferometry.
Our results show that experiments with trapped ion clocks are within reach of probing relativistic evolution of clocks for which a quantum description of proper time becomes necessary."

Scientists at Stevens Institute of Technology Reveal That Time Can Go Quantum in Ion Clock Experiments "Physicists show that atomic clocks can probe time ticking both faster and slower simultaneously, revealing how time itself unfolds in quantum superposition"

Credits: Einstein trifft Quantenphysik: Wenn Zeit gleichzeitig schneller und langsamer läuft "Physiker testen ein radikales Szenario: Zeit könnte gleichzeitig schneller und langsamer vergehen. Atomuhren machen es prüfbar."


Illustration of classical, semiclassical, and quantum proper time dynamics of a trapped-ion atomic clock that we consider. 



Illustration of time-dilation-induced entanglement between clock and motional degrees of freedom, and how it can be observed using trapped atomic clocks with squeezing of motional states. The protocol proceeds from left to right.
The top row shows the motional states in a phase-space representation, where a squeezed state is prepared which then evolves at different frequencies in superposition, depending on the internal clock states.
The bottom row shows the same sequence from the perspective of the clock degrees of freedom represented on a Bloch sphere, where a Ramsey sequence results in a superposition of different time evolutions of the clocks due to the different motional energies.
The entanglement between motion and clock (last column) causes a reduction in visibility of the clock ... which can be measured with current state-of-the-art ion clock systems.


Researchers have imaged every single cell in the body of a newborn mouse

Amazing stuff! 

"Researchers have imaged every single cell in the body of a newborn mouse, using a custom fluorescence microscope, high-speed cameras and an atlas of the mouse body onto which they mapped data. 

“Since Robert Hooke first described cells in 1665, more than 360 years have passed,” ... “Yet no one had directly visualized all cells in mammalian organs or in the whole body of a newborn mammal at single-cell resolution.” They also mapped responses to drug toxicity at a single-cell scale."

Nature Briefing: Translational Research

Establishing whole-body cellomics (partially behind paywall)





Nuclear magnetic resonance (NMR) is coming back into vogue among drug developers

Good news!

"Nuclear magnetic resonance (NMR) could be on the brink of a renaissance among drug developers.

For decades, other techniques that assess the structure of drugs — such as X-ray crystallography and, more recently, cryo-electron microscopy — have overshadowed NMR because of its complexity and slowness.

But over the past five years, a suite of contract research organizations (which manage research for drug companies) have been founded with the aim of bringing NMR back into the limelight as the technology improves, to help drug discovery.

Meanwhile, NMR has been used to uncover a completely new conformational state in a group of proteins strongly linked with cancer progression. The newly discovered ‘invisible fold’ in kinases could help make kinase inhibitors more selective. “Conformational dynamics in drug discovery are critical and underappreciated,” ..." 

Nature Briefing: Translational Research

NMR-as-you-go for drug hunters (no public access) "Craving speed and convenience, biopharma companies turn to providers with NMR know-how."

Autonomous, chinese made humanoid Robot beats human world record at Beijing half-marathon

Amazing stuff!

"The winning runner at a Beijing half-marathon for humanoid robots finished the race today in 50 minutes and 26 seconds — significantly faster than the human world record of 57 minutes recently set by Jacob Kiplimo. ...

this year’s winner was built by Chinese smartphone maker Honor.  ... the 50:26 robot was autonomous and won due to weighted scoring. ...

About 40% of participating robots competed autonomously, while the remaining 60% were remote controlled ..."

Robots beat human records at Beijing half-marathon | TechCrunch

Humanoid robot sprints to victory in Beijing, beating human half-marathon record "A humanoid robot has won a half-marathon race for robots in Beijing, running faster than the human record"






Higher Oil prices? China mysteriously reduced warplane activity near Taiwan over the past three weeks

Good news! 😊 Maybe a welcome relief for Taiwan!

" Could it be high fuel prices, or a desire to avoid upsetting U.S. President Donald Trump? What about China’s annual political confab in early March? Analysts have offered different explanations for a recent trend: a net reduction in daily Chinese fighter plane activity near Taiwan over the past three weeks. ..."

Oil prices, fear of Trump? China mysteriously reduced warplane activity near Taiwan

Female Teacher’s Aide Charged with Sexual Conduct with Student, 15, Sent Him Her Positive Pregnancy Test

Another Me Too event!

Teacher’s Aide Charged with Sexual Conduct with Student, 15, Sent Him Her Positive Pregnancy Test "An Arizona school aide is scheduled for a hearing this week on charges she had a sexual relationship with a 15-year-old student during which she sent him her positive pregnancy test and discussed how they could force a “miscarriage." ..."

Leftist Southern Poverty Law Center Was indicted as a Funder of White Supremacist Groups

What a mutually beneficial symbioses! What a nice arrangement!

If confirmed, this is pretty bad! What do some political, activist NGOs do?

I have little doubt that these allegations could turn out to be true!

"US officials have announced fraud charges against the Southern Poverty Law Center (SPLC), a civil rights group that tracks extremist organisations and played a prominent role in confronting the Ku Klux Klan (KKK).

In a news conference on Tuesday, Acting Attorney General Todd Blanche accused the non-profit of secretly funding the very groups that it says it opposes, through paying informants who infiltrated them - including within the KKK.

An indictment charges the SPLC with six counts of wire fraud, four counts of bank fraud and one count of conspiracy to commit money laundering. ..."

Southern Poverty Law Center Was the Largest Funder of White Supremacist Groups | Frontpage Mag "The SPLC had been financing what it claimed to be fighting"

Russia, Turkey And Other countries Engage with African Autocrats

Recommendable! What are Russia and others up to?

Caveat: I did not read the entire, long article!

Us Competes With Russia And Others As It Engages African Autocrats: Africa File Special Edition | Critical Threats


Figure 5. Russia Pursues Mediterranean Sea to Atlantic Ocean Corridor


Figure 6. Madagascar Moves Closer to Russia


Figure 8. United Arab Emirate backed Rapid Support Forces (RSF) Regional Smuggling Supply Lines


Tuesday, April 21, 2026

Trump expedites review of psychedelics to treat mental health disorders funded with $50 million

Good news! A nation of junkies by executive order? Just kidding!

We ought to find better cures than administering psychedelic drugs!

"President Trump has signed an executive order to make certain psychedelic drugs more available to treat mental health conditions, such as depression and anxiety. He directed $50 million in federal funds to make them more accessible, and ordered the Food and Drug Administration to fast track a review of such drugs as psilocybin and ibogaine.

"Can I have some, please?" Trump joked to a laughing audience in the Oval Office. ..."

Trump expedites review of psychedelics to treat mental health disorders : NPR




Designing better weapons to fight prostate cancer based on distinct tissue niches

Good news! Cancer is history (soon)!

"... A new study in the journal Immunity reveals that the prostate has its own defense force and unlocks key insights into how this army of cells, known as tissue-resident memory CD8 T cells, or Trm cells, works.

“We found that different types of T cells live in different areas, or neighborhoods, within the tissue, and where they live determines how they behave,” ..."

From the highlights and abstract:
"Highlights
• Long-lived prostate Trm cells protect against reinfection
• The prostate Trm population is heterogeneous in mice and humans
• IL-15, IL-7, and TGFβ differentially regulate prostate Trm cell subsets
Distinct prostate cytokine and chemokine niches define Trm cell heterogeneity

Summary
The prostate is an important exocrine organ, a barrier tissue of the male reproductive system, and a common site of malignancy, yet CD8+ T cells in the prostate remain largely uncharacterized.
Here, we show that a protective, heterogeneous pool of long-lived, tissue-resident memory CD8+ T (Trm) cells forms in the prostate following acute infection in mice.
Characterization of prostate Trm cell differentiation over time, combined with functional interrogation of TGFβ, IL-7, and IL-15 signaling, revealed niche-dependent phenotypic and functional diversity arising from distinct prostate stromal and glandular epithelial niches in both mice and humans
For instance, the Trm-promoting cytokines IL-15 and TGFβ were highest in the prostate epithelium, where CD8+ T cells were most persistent, cytotoxic, and enriched for the Trm molecular program.
In sum, we provide a spatial framework for prostate Trm cell differentiation, charting the discrete tissue regions that influence T cell fate through dynamic regulation of localized signals."

Designing better weapons to fight prostate cancer - Allen Institute "New study unlocks key insights that could help develop next-generation immunotherapies"



Graphical abstract




Ten different animal species feast on bats in a Ugandan cave offering clues to how deadly viruses spread

Serious stuff!

"When researchers in Uganda set up camera traps to monitor African leopards (Panthera pardus pardus) and spotted hyenas (Crocuta crocuta) in a national park last year, they had no idea that they would record so much more than just those animals. Several of the traps, placed outside a cave known to host Egyptian fruit bats (Rousettus aegyptiacus), caught on video a multitude of creatures feasting on the winged mammals. The bats are known carriers of Marburg virus, which can transfer into humans and cause a fatal haemorrhagic fever, so the footage offers real-time insight into how disease can spread.

Scientists know that bats can transmit viruses to humans either directly, or through an intermediate animal, from forensic detective work and other studies. The team in Uganda thinks this is the first time that potential intermediate animals have been caught on camera in a known hotspot for Marburg virus, which is in the same family as Ebola virus. ..."

‘Bat feast’ animal videos at African cave offer clues to how deadly viruses spread (partially behind paywall) "Researchers filmed 10 species eating or scavenging bats at known Marburg-virus hotspot — and caught hundreds of humans visiting."

Der Weg in den Ökosozialismus: Top-Ökonom Lars Feld kritisiert wachsenden Subventionsstaat

Sehr empfehlenswert! Der Klimawahn tobt in der Bananenrepublik D!

Lars Feld beschreibt die seit Jahrzehnten wohlbekannten liberalen Argument warum zu großer Staat (Leviathan, Hayek's Weg zur Knechtschaft) schädlich für die Freiheit und Marktwirtschaft ist.

"Welche Rolle soll in unserer Ökonomie der Staat einnehmen? Ist es seine Aufgabe, neben der Garantie äußerer und innerer Sicherheit sowie der Rechtspflege überhaupt in der Ökonomie zu intervenieren? Mit Blick auf die gegebene Realität des wuchernden Staatsapparats müssen wir konstatieren: Seit 2015 hat er auf allen Ebenen versagt [seit der schrecklichen SED Kanzlerin Merkel] ...

Der Freiburger Ökonom Lars Feld warnte am Wochenende im Interview mit dem Tagesspiegel vor dieser Entwicklung. Feld rechnete vor, dass im laufenden Jahr etwa 7 Prozent des Bruttoinlandsprodukts, also 321 Milliarden Euro an Subventionen, Beihilfen und anderen Marktmanipulationen durch den Staat verteilt werden. Ein nicht endender Strom an Fördermitteln – böswillige Zungen würden sagen: Schmiergeld – ergießt sich über das Land. Viele reiben sich die Hände. Diejenigen, denen bewusst ist, dass sie für das Freibier aufkommen müssen, reagieren mit zunehmender Apathie.

Es ist ein Staat im Staate entstanden, ein gigantischer parasitärer Körper, der dem produktiven Teil der Gesellschaft die Mittel entzieht, um den wachsenden Teil der in Abhängigkeit gebrachten Subventionsjäger und Staatsangestellten ein sorgloses Einkommen zu garantieren. So schafft man sich politische Mehrheiten, stürzt aber gleichzeitig die Ökonomie in den Abgrund.
7.000 Euro pro Arbeitnehmer beträgt der Subventionsberg im Jahr, rechnet Feld vor, bei inzwischen 5,5 Millionen Beschäftigten im öffentlichen Dienst und einer Staatsquote von weit über 50 Prozent.

Der kafkaeske Staatsapparat hat längst ein Eigenleben entwickelt – er ist zu einer gefräßigen Maschine degeneriert, die das Wallensteinsche Motto auf den Punkt bringt: „Der Staat nährt den Staat“. Es wird keine Reformen mehr geben, bis dieses Gebilde nicht unter seinem eigenen Gewicht kollabiert. Zu viele Individuen, Firmen, Strukturen, NGOs, Medien besitzen einen vitalen Anreiz, diese Umverteilungsstruktur zu verteidigen. Feld hat recht, wenn er sagt: „Subventionen setzen falsche Signale und führen zu ökonomischer Erstarrung“. ..."

Top-Ökonom kritisiert wachsenden Subventionsstaat "Der Umbau der deutschen Industrie in eine zentral geplante Transformationswirtschaft verbrennt das Zukunftspotenzial unserer Gesellschaft. Der Freiburger Ökonom Lars Feld zählt zu den wenigen Wissenschaftlern, die den entgrenzten Subventionsrausch des Staates noch zu durchschauen vermögen."


Lars Feld, Director des Walter Eucken Instituts







Bundeskanzler Merz sieht gesetzliche Rente nur noch als "Basisabsicherung". Wirklich!

Schlechte Nachrichten! Was fuer ein Betrug durch den Staat! Ungeheuerlich!

Dann wird es Zeit die gesetzliche Rentenversicherung (staatliche Zwangsversicherung) abzuschaffen! Lasst die Bürger für sich selbst sorgen im Alter!

"... Beim Jahresempfang des Bundesverbands deutscher Banken in Berlin formuliert Friedrich Merz die neue Leitlinie für die Altersvorsorge in Deutschland: Die gesetzliche Rentenversicherung werde künftig nur noch „Basisabsicherung“ leisten und den Lebensstandard nicht mehr sichern. Wer einzahlt, kann nicht mehr davon ausgehen, eine Leistung zu erhalten, die sich an seiner eigenen Erwerbsbiografie orientiert. Die Verbindung zwischen Einzahlung und Anspruch ist aufgehoben. ..."

Und es ist weg: Merz sieht gesetzliche Rente nur noch zur "Basisabsicherung" "Und es ist weg: Das Geld und die Beiträge der Bürger sind ausgegeben, verteilt, verschwendet, verbraucht. Friedrich Merz erklärt die gesetzliche Rente faktisch für gescheitert. Für Millionen Beitragszahler bleibt die Finanzierung eines maroden Systems, das sie selbst nicht mehr absichert. Selbst in der kanzlerergebenen CDU wächst der Widerstand."

English for trippers: A receipt for a recipe

Recite it!

Iranian-backed Iraqi militias conducted up to half of the roughly 1,000 drone attacks targeting Saudi Arabia

Bad news! What to do about that?

"... Iranian-backed Iraqi militias conducted up to half of the roughly 1,000 drone attacks targeting Saudi Arabia during the war, according to unnamed sources speaking to the Wall Street Journal on April 21. CTP-ISW previously assessed that it very unlikely that Iranian-backed Iraqi militias would conduct drone attacks against regional states if the Iranian regime opposed such attacks, which suggests that Iran has not ordered its militia partners to cease attacking regional state. ..."

Iran Update Evening Special Report, April 21, 2026

Australia gets new military leaders, including first female army chief

Good news! Bravo!

This is old news, but I was not able to blog about it earlier thanks to the Great Firewall of China.

Australia gets new military leaders, including first female army chief "Lieutenant General Susan Coyle will take up her new appointment in July"


Lieutenant General Susan Coyle



Japan loosens arms exports rules in major shift

Good news! Bravo! More signs that Japan is giving up it's strict pacifism since 1945 under the new Prime Minister Sanae Takaichi!

Margaret Thatcher is smiling!

"... “In an increasingly severe security environment, no single country can now protect its own peace and security alone, and partner countries that support each other in terms of defense equipment are necessary,” Takaichi wrote on her X account today. “Meeting such needs and carrying out transfers of defense equipment will contribute to enhancing the defense capabilities of these countries and, ultimately, to preventing the outbreak of conflicts, thereby contributing to Japan’s security.”

Today’s announcement by the Cabinet Secretariat means Japan will now be able to export lethal equipment to 17 countries that it has signed defense equipment and technology transfer agreements with, including the US, United Kingdom, Australia, and India. ..."

Japan loosens arms exports rules in major shift "Tokyo's shift clears the way for arms exports to partners and allies."

Trump’s madman diplomacy isn’t working on Iran. Really!

The author (CATO Institute analyst Benjamin Giltner) presents another version of Trump Derangement Syndrome! The author appears to be a lunatic!

What have all the tame US Presidents since 1979 (except President Reagan) achieved versus the fanatic, suicidal, terrorism sponsoring theocratic dictatorship in Iran? Not very much!

President Trump may turn out to end this regime and become the most consequential US President since 1979

Caveat: I did not read the entire article.

"... Why didn’t the president’s maximalist threats work? Indeed, his bombastic form of diplomacy appears to have undermined the prospects for peace between the United States and Iran. To understand why Trump has failed to change Iran’s behavior, it is necessary to examine his approach to diplomacy. ..."

Trump’s madman diplomacy isn’t working on Iran


Benjamin Giltner


US forces intercepted ‘gift from China’ to Iran, President Trump says

Bade news! Serious stuff! Will the Iran war expand to other countries?

US forces intercepted ‘gift from China’ to Iran, Donald Trump says (behind paywall) "US president says Beijing had sent something ‘that wasn’t very nice’ and he thought he had an ‘understanding’ with Xi Jinping"

Monday, April 20, 2026

When the once prestigious AAAS again promotes demagoguery and fallacies

Bad news! What a shame and pseudoscience by the American Association for the Advancement of Science (AAAS)!

Because of the global reduction in air pollution, now we have to reflect the "sun's radiation back to space"? What a nonsense!

"Global warming [???] is bad news for polar bears, seals, and walruses; the Arctic sheets of seasonal sea ice they frequent have been on the decline for decades.
An ambitious idea seeks to intervene: sea ice thickening [???], where engineers drill through the ice and pump up ocean water to freeze on top in an attempt to delay summertime melting. If successful, the extra ice would also make the poles brighter, reflecting more of the sun’s radiation back to space [???] and lessening a dangerous climate feedback loop.

Like all geoengineering ideas, it’s controversial. But field trials have begun, and the first results are out: while pumping thickens ice, those gains don’t stick around. ..."

"A simple idea [??] underpins an audacious intervention to augment Arctic sea ice and slow the climate feedback loop accelerating its disappearance. Drill holes through a floe, pump seawater onto its surface, and let the cold do the rest. The first results from two field tests show the technique can thicken the ice. But they also show those gains don’t last. ..."

ScienceAdviser

Artificially engineered sea ice grows—but tests are too small to combat melting "First Arctic trials show pumped seawater can bulk up ice, but results aren’t lasting—and may not scale"

UN-Skandal: Deutschland nominiert Irans Terrorregime für Gremium zu Menschen- und Frauenrechten mit

Unglaublich, falls bestätigt! Ein Fall von wenn man den Bock zum Gärtner macht?

Wie blöd oder unbedarft ist der gegenwärtige Bundeskanzler der Bananenrepublik D ?

UN-Skandal: Deutschland nominiert Irans Terrorregime für Gremium zu Menschen- und Frauenrechten mit "Deutschland hat das mörderische Terrorregime des Iran im UN-Wirtschafts- und Sozialrat mit für ein Gremium nominiert, das über Menschen- und Frauenrechte berät. Auf dem Höhepunkt des anschließenden Shitstorms versucht sich das Auswärtige Amt nun aus dieser skandalösen Verantwortung herauszureden."

CDU Fraktionsvorsitzender Spahn gesteht: „Im Moment verwalten wir weitestgehend den Niedergang“

Schlagzeile des Tages aus der Bananenrepublik D!

Lebenslange Berufspolitiker wie Spahn sind oft nicht die hellsten!

Spahns herausgerutschtes Geständnis: „Im Moment verwalten wir weitestgehend den Niedergang“ "„Im Moment verwalten wir weitestgehend den Niedergang.“ Was Jens Spahn (CDU) bei Caren Miosga ausspricht, ist kein Lapsus, sondern Selbstentlarvung: Der Staat betreibt den Abstieg des Landes als Dauerprojekt. Dabei wird der Niedergang der Regierungsparteien wenigstens gleich mitverwaltet."


Jens Spahn


Parteipolitik im Regierungsamt: Klingbeil reist als Finanzminister zu sozialistischem Weltkongress in Barcelona – mit Merz’ voller Zustimmung

Neues aus der Bananenrepublik D!

Der Bundesfinanzminister hatte wohl nichts wichtigeres zu tun!

"Als Bundesfinanzminister reist Lars Klingbeil auf Steuerzahlerkosten zu linken Weltkongressen nach Barcelona und ruft dort zum sozialistischen Klassenkampf sowie zum globalen Kampf gegen Rechts – mit voller Rückendeckung von Friedrich Merz. Das Wohlwollen des Kanzlers mit der V. Internationale. ..."

Parteipolitik im Regierungsamt: Klingbeil reist als Finanzminister zu Sozialistentreff – mit Merz’ Zustimmung




France, Germany Propose ‘Symbolic’ EU Membership Path for Ukraine Without Voting Rights

Good news! About time!

"France and Germany are proposing a “symbolic” form of European Union integration for Ukraine that would grant limited benefits before full membership, according to a report by the Financial Times published on Monday, April 20.

The plan would allow Ukraine to participate in EU meetings but without voting rights and without immediate access to key parts of the bloc’s budget, including agricultural subsidies and regional funding.

Germany is advocating for an “associate membership” model, while France has suggested a similar concept described as “integrated state status,” both of which would delay full financial and political integration until Ukraine completes the standard accession process. ..."

France, Germany Propose ‘Symbolic’ EU Membership Path for Ukraine Without Voting Rights "Paris and Berlin are pushing a staged approach that would delay full access to EU funds and decision-making power."

Ukraine Signs 10-Year Defense Export Deals With 3 Middle East Countries

Good news!

"Ukraine has signed 10-year defense export agreements with Saudi Arabia, the United Arab Emirates and Qatar, President Volodymyr Zelensky said, as Kyiv expands cooperation with Middle Eastern countries on drone warfare and integrated air defense systems. ..."

Ukraine Signs 10-Year Defense Export Deals With 3 Middle East Countries "The agreements come as Middle Eastern countries face growing drone threats following recent escalations in the region, including large-scale strikes involving low-cost UAVs."


This handout picture released by Qatar’s Amiri Diwan shows Qatar’s Emir Sheikh Tamim bin Hamad Al-Thani receiving Ukraine’s President Volodymyr Zelensky at Lusail Palace in Doha on March 28, 2026.
The sheikh & the comedian! 😊


Discovery could lead to new therapies for blood disorders

Good news!

"... investigators have revealed the detailed workings of a cell membrane protein that has essential roles in all animals. The discovery could lead to new therapeutic strategies for blood coagulation disorders, cancers and other conditions in which the protein, called a TMEM16 scramblase, works abnormally.

Scramblases operate within cell membranes, where they alter or “scramble” the normal layered arrangement of lipid molecules – an essential step in many biological processes. The scramblase TMEM16F also works as an ion channel, allowing small, charged molecules such as potassium or chloride ions through the membrane. ...

the researchers at last attained this goal by embedding the protein in liposomes – tiny lipid capsules – which allowed them to image its active and inactive structures at near-atomic-scale resolution. ...

TMEM16F’s rearrangement of cell membrane lipids enables platelet cells to clump together to make blood coagulate, and a mutation affecting the scramblase underlies Scott syndrome, a hemophilia-like bleeding disorder.
The protein is also involved in the formation of the placenta in pregnancy, bone development and immune functions; and it is exploited or suppressed in various cancers and infections. ..."

From the abstract:
"The ubiquitous transmembrane protein 16F (TMEM16F) Ca2+-activated channel and scramblase catalyzes phosphatidylserine externalization to enable blood coagulation, membrane fusion and brain immune surveillance.
Despite its importance, the molecular mechanisms underlying TMEM16F activation remain poorly understood.
Here, we obtained high-resolution cryo-electron microscopy structures of TMEM16F active in liposomes. In high-activity conditions, TMEM16F adopts two conformations, the canonical Ca2+-bound closed state and one where the upward rotation of the cytosolic domain leads to an X-shaped groove that forms a transmembrane pore and locally thins the membrane.
Using mutagenesis, functional assays and molecular dynamics simulations, we show that the X-shaped groove is active and mediates nonselective ion flux and lipid scrambling through distinct pathways; ions move within the protein-delimited pore, whereas lipids skirt the X-shaped groove.
Our findings provide a complete picture of TMEM16F Ca2+-dependent gating and demonstrate that imaging membrane proteins in a native-like environment can allow capturing otherwise inaccessible active states."

Discovery could lead to new therapies for blood disorders | Cornell Chronicle



Fig. 1: Structure of purified TMEM16F reconstituted in liposomes.


Fig. 5: Activation of TMEM16F.


Xi Jinping says Strait of Hormuz should be open in call to Saudi Crown Prince

Headline of the day!

Nice indirect order/intervention aimed at Iran to stop messing with the Strait of Hormuz! Bravo!

Xi Jinping says Strait of Hormuz should be open in call to Saudi Crown Prince

Sunday, April 19, 2026

On Momentum Further Constrains Sharpness at the Edge of Stochastic Stability

This could be an interesting, but narrowly focused, new paper by Tomaso Poggio and his team!

Caveat: I have not read the paper (40 pages total) yet.

From the abstract:
"Recent work suggests that (stochastic) gradient descent self-organizes near an instability boundary, shaping both optimization and the solutions found.
Momentum and mini-batch gradients are widely used in practical deep learning optimization, but it remains unclear whether they operate in a comparable regime of instability.
We demonstrate that SGD with momentum exhibits an Edge of Stochastic Stability (EoSS)-like regime with batch-size-dependent behavior that cannot be explained by a single momentum-adjusted stability threshold.
Batch Sharpness (the expected directional mini-batch curvature) stabilizes in two distinct regimes:
at small batch sizes it converges to a lower plateau , reflecting amplification of stochastic fluctuations by momentum and favoring flatter regions than vanilla SGD; at large batch sizes it converges to a higher plateau , where momentum recovers its classical stabilizing effect and favors sharper regions consistent with full-batch dynamics.
We further show that this aligns with linear stability thresholds and discuss the implications for hyperparameter tuning and coupling."

[2604.14108] Momentum Further Constrains Sharpness at the Edge of Stochastic Stability