Sunday, August 23, 2026

What is Missing from large language model AI Post-Training AI: An Empirical Analysis

This could be an interesting new paper by Maosong Sun and his team.

From the abstract:
"Large language model (LLM) agents can now post-train an LLM end-to-end. They can write code, launch training, evaluate checkpoints, and improve downstream performance, raising the prospect of AI-for-AI.
We argue that this picture conflates two distinct capabilities:
execution-level capability, iterating within a selected training strategy; and strategy-level capability, revising the high-level judgment as experimental evidence accumulates.
Analyzing a large corpus of publicly released post-training trajectories, we find that across different tasks, the agent's training strategy is locked in at the very beginning, and the entire remaining budget is spent on local adjustments within the selected strategy.
We then examine three natural explanations -- missing experience, missing guidance, and insufficient reasoning--with escalating interventions.
Extensive experiments show that
(1) an experience-driven scaffold improves execution across the board (+12.6 points on GSM8K and +40.8 on HumanEval) but leaves the strategy static;
(2) human guidance effectively redirects the initial strategy, yet the agent falls back into local adjustment loops once training starts; and
(3) additional inference compute pays off on easier tasks but yields almost no gain on the hardest one.
In conclusion, what agents lack is neither experience, guidance, nor reasoning compute, but a mechanism for spontaneously reevaluating their strategy during execution."

[2608.19072] What is Missing from AI Post-Training AI: An Empirical Analysis (preprint, open access)






SPADE: Self-Play in Adaptive Synthetic Executable Environments

This could be an interesting new paper by Luke Zettlemoyer & Yejin Choi and their team!

From the abstract:
"Continuous self-improvement requires an ever-expanding pool of self-generated, diverse, adaptive goals.
For language agents, existing training environment pools (hand-curated, statically synthesized, or frozen-verifier) keep the goal distribution fixed as the learner scales.
We introduce SPADE (Self-Play in Adaptive Synthetic Executable Environments), a self-play RL framework in which a single LLM plays two roles:
an Environment Designer that writes complete, long-horizon training environments as executable code with an OpenAI Gym-style reset()/step() interface, and a
Reasoning Agent that learns to act in them.
Each is a stateful, multi-turn environment (state transitions, reward functions, and verification code), so one interface spans reasoning problems and multi-step agentic tool use.
The Reasoning Agent's regret is estimated using the gap between its reward with and without privileged hints; in optimizing this regret signal the Environment Designer learns to target environments at the edge of the agent's capabilities while keeping them feasible.
Through extensive experimentation, we find several components critical to success: grounding the Environment Designer on documents sampled from a large pretraining corpus, and giving it an accumulated environment memory.
Scaling to 30B-parameter models, SPADE improves over the strongest fixed-environment baseline by +5.3 on average across eight held-out math, science, code, and reasoning benchmarks, and lifts the tool-use setting by +5.7 on BFCL-v4 multi-turn and +13.9 on ACEBench-Agent; on the games setting, the margin over the strongest baseline grows with model scale.
By making environment design itself a learnable component, SPADE takes a concrete step toward open-ended self-improvement."

[2608.19197] SPADE: Self-Play in Adaptive Synthetic Executable Environments (preprint, open access, 76 pages)








Sedimentary rocks from east India point to early traces of life about 3.5 billion years ago

Amazing stuff! Out of Africa or out of India?

It appears the German University of Technology in Oman has done similar research in Singhbhum Craton, India at least since March 2024, see Sedimentology and geochronology of Mesoarchean siliciclastic successions of the Singhbhum Craton, India and their implications

"Early in Earth’s history, the planet was covered in oceans. But the real hotspots were hydrothermal environments, where volcanic and tectonic activity provided the energy and nutrients needed for life to develop.
Over 3 billion years later, sedimentary rock formations known as cherts preserve traces of these ancient landscapes. Now, a new study presents evidence that they contain traces of life, too. ...

The findings provide the earliest evidence of life’s carbon signatures from a directly dated rock sample, reinforcing previous estimates of when life began."

From the significance and abstract:
"Significance
Kerogen, insoluble organic matter preserved in sediments, represents some of the earliest known terrestrial biosignatures which have provided important insights into the origin of life and planetary habitability.
Direct dating of these materials can be complicated by the lack of suitable geochronometers, instead relying on indirect constraints from, for example, the age of cross cutting lithologies.
Here, we report a 3.5-billion-year-old carbonaceous chert from eastern India containing what are interpreted to be contemporaneous tuffaceous zircons.
The chert exhibits micron-scale alternating layers of carbonaceous and siliceous materials
δ13C isotope data of carbonaceous matter (CM) together with stratigraphic relationships indicate a biogenic origin of the kerogen marking this to our knowledge the oldest directly dated rock with a confirmed biosignature.

Abstract
Zircons interpreted to be of syn-volcanic origin recovered from the lower greenschist “black and white banded” Bhitardari chert, Eastern Iron Ore greenstone belt, Singhbhum craton, India, yield a 207Pb/206Pb zircon age of 3497 ± 5 Ma (n = 4; MSWD = 1.2).
This chert contains abundant carbonaceous matter (CM) that occurs in two textural modes:
1) ultrafine laminae distributed within the matrix and
2) graphite flakes in late quartz veins.
Bulk δ13CCM of both modes in the Bhitardari chert yield a value of −30.9‰, which we interpret as reflecting a biogenic origin.
This represents the documentation of a directly dated, CM-bearing, Paleoarchean rock with δ13CCM diagnostic of biologic activity.
The observed isotopic compositions are consistent with the rise of relatively sophisticated metabolic mechanisms (e.g., Calvin cycle) by 3.5 Ga."

ScienceAdviser


Direct dating of 3.5 Ga biogenic carbon in a microbial mat remnant, Singhbhum Craton, India (This repository appears to provide access to the research article PDF file)






German University of Technology in Oman since 2007

Amazing stuff! I did not know or forgot there was such a thing as GUtech in Oman!

It appears to be affiliated with the RWTH (Rheinisch-westfälische Technische Hochschule).

GUtech at a glance - GUtech




Israel’s elderly employment rate among OECD’s highest

Israel is always good for positive surprises (presumint this one is based on voluntary individual choices)! 😊

Israel has a gender equality problem, the official retirement age between men and women is a staggering five years apart, i.e. 67 versus 62.

Notice Israel has a rather high official retirement age of 67 for men.

"... A significant number of them work in security, education, and transportation and the vast majority are men. ...

While most Israelis who continue to work after the official retirement age (67 for men and 62 for women) leave their jobs shortly thereafter, the presence of men at particularly old ages, 70+, is even more striking.

Of men who work past the retirement age, over 58% continue to work even after the age of 70. For women, the rate is much lower - only 29%. ..."

Israel’s elderly employment rate among OECD’s highest - Globes "According to data from the Shoresh Institute, about 28% of men and about 15% of women over the age of 65 continue to work."

California regulators have approved a major expansion of Waymo’s driverless taxi service across parts of 18 counties including new areas

Good news!

"... The company is now authorized to offer paid robotaxi rides across parts of 18 counties, including new areas around Sacramento, San Diego, Orange County, Napa, and the East Bay of San Francisco."

Doomslayer: Progress Roundup - by Malcolm Cochran

The US Food and Drug Administration (FDA) has authorized a standalone Dutch robot that can draw blood

Maybe the first approved vampire robot? 😊 And the FDA released the announcement on my birthday! 😊

"... The machine, called Aletta, uses near-infrared light and ultrasound to locate a vein before autonomously applying a tourniquet, disinfecting the skin, inserting the needle, changing collection tubes, and applying a bandage.
The authorization will allow Aletta to be used on adults in clinics and other medical settings where patients do not stay overnight."

"... The device is authorized for use in adults in outpatient settings and must be operated under the oversight of a supervisor trained in phlebotomy.
One phlebotomist can oversee up to three Aletta devices at the same time ..."

"... The Aletta ARPD is designed to autonomously perform diagnostic blood collection. The system combines multimodal imaging, including near-infrared, ultrasound, and Doppler ultrasound to help distinguish between veins and arteries. It combines these capabilities with advanced robotics and artificial intelligence, to identify suitable veins, guide needle insertion, and collect blood samples with high precision and consistency. ..."

Doomslayer: Progress Roundup - by Malcolm Cochran

US Authorizes First Standalone Robotic Blood Draw Device

FDA Authorizes First-Of-Its-Kind Robotic Blood Draw Device (original news release) "Authorization supports innovative approach to blood collection; may help address growing phlebotomist shortage"

Discover how Aletta® sets a new standard for blood collection "Aletta, the world’s first Autonomous Robotic Phlebotomy Device (ARPD), automates the diagnostic blood collection process."



Aletta




Americans say they are gambling less than they were a decade ago. Really!

Maybe the survey design was flawed? Maybe some individuals do not self report their gambling activities anymore as they used to? Maybe other or novel forms of gambling are preferred, but not surveyed? 

Notice in chart 1 below there was a 5 percentage point gain of which 4 percentage points came from a new category of gambling (i.e. fantasy sports games).

Notice in chart 3 below that the method of survey taking makes already an 8 percentage point overall difference.

"Americans say they are gambling less than they were a decade ago. According to a recent Gallup poll, 45 percent of US adults reported gambling in the past 12 months in 2026, down from 64 percent in 2016." 

Doomslayer: Progress Roundup - by Malcolm Cochran


Fewer U.S. Adults Say They Gamble (original news release) "Among all major subgroups, reported participation in a range of gambling activities is lower"


Chart 1 (Source)


Chart 2 (Source)


Chart 3 (Source)


Europeans are using a lot more air conditioning recently

Good news! Let cooler heads prevail! Just kidding!

Is it climate change or increased human sensitivity to warm temperatures (e.g. aging population etc.)?

"... The amount of energy used for household cooling in the EU has doubled since 2018, though from a low base.
In 2020, American households used around 914,000 terajoules to power air conditioning, compared to just 45,000 in Europe.
Chinese air-conditioner exports to the EU reached a record $3.76 billion in the first half of 2026, up 43 percent from a year earlier."

Doomslayer: Progress Roundup - by Malcolm Cochran

Iranian cyberattack shuts down British power plant for four days

Bad news! Is this dawn of the age of cyber wars!

I blogged here recently about what could be a similar attack on water treatment plants in Minnesota and 11 other US states. ...

Though British officials have not named the targeted power plant, citing security concerns, the outlet noted that it is "relatively small" and, as such, the attack did not affect the UK's national power supply or its ability to generate power. ..."

"Iran shut down a British power plant for four days in an unprecedented cyber attack, The Telegraph can disclose.

It is thought to be the first time that hackers affiliated to the Iranian regime have succeeded in closing down such a facility in the UK, and is believed to be the most successful cyber attack of its kind. ..."

Iranian cyberattack shuts down British power plant for four days | The Jerusalem Post "The attack occured during the reported Iranian cyberattack that targeted over 30 municipal water systems in Minnesota and several other states in the US, according to the Telegraph."

Iranian hackers shut down UK power plant "Unprecedented cyber attack believed to be most successful of its kind"

Image of the day

A book cover! (Source



Chipmaker Nvidia is spending $6 billion on AI

AI is not cheap! AI runs on powerful chips, but is a chipmaker a good candidate for advanced AI? Or is the charismatic CEO Jensen Huang going too far?

"That’s how much Nvidia is spending as it tries to build one of the world’s most powerful open-weight AI models. The effort is aimed at competing with Chinese heavyweights and American AI giants."

The Wall Street Journal What's news


Jensen Huang (official photo, source)


Are the U.S. and Canada spiraling toward a full-blown trade war?

Bad news! Whatever happened to the North American free trade zone (aka NAFTA) since 1994?

Are we having here two old men in a contest of wills?

"After weeks of marathon talks between U.S. and Canadian trade officials, an agreement was almost in sight. Then, late on Friday, the talks collapsed at the 11th hour. Tariffs of 50% on $20 billion worth of Canadian goods went into effect, and Ottawa said it will respond with dollar-for-dollar levies on Sept. 8."

The Wall Street Journal What's news


Mark Carney (age 61) and Donald Trump (age 80) (Source)


Prince, Prince and The Revolution - Little Red Corvette (Live in Syracuse, NY, 3/30/85)

Enjoy!

Prince, Prince and The Revolution - Little Red Corvette (Live in Syracuse, NY, 3/30/85) - YouTube


Saturday, August 22, 2026

Japanese companies tap into China's eldercare boom

Good news! Japanese businesses have some experience with an aging Japanese population.
Japanese companies tap into China's eldercare boomーNHK WORLD-JAPAN NEWS - YouTube


Stevie Wonder - Living For The City (1974) | LIVE

Enjoy!

(149) Stevie Wonder - Living For The City (1974) | LIVE - YouTube


Could Turkey’s New Party Oust Erdoğan?

Recommendable! Osman Sultan Erdogan has been in power for way too long!

(146) Could Turkey’s New Party Oust Erdoğan? - YouTube


Chinese robot smashes Usain Bolt’s 100m record at World Robot Games

Very impressive! But humans do not need stretchers or fire extinguishers after the race. 😊

(146) Chinese robot smashes Usain Bolt’s 100m record at World Robot Games - YouTube


Full Self-Driving Is the Best Thing About the New Tesla Model Y

Does the car still have a steering wheel? 😊

2026 Tesla Model Y Review: Software, Take the Wheel - WSJ (behind paywall) "Facing stiffer competition from rivals, Tesla’s updated Model Y relies on its street-savvy software to maintain an edge"

British Kids Are Skipping Top Colleges for White-Collar Apprenticeships

We have seen similar headlines for other Western countries and over the past 10-20 years or so.

A recurring theme in Western news reporting! Is it different this time?

British Kids Are Skipping Top Colleges for White-Collar Apprenticeships - WSJ (behind paywall) "College no longer feels like a good deal for high-school graduates, so they are heading straight into the workforce"

Clown Governor Walz bans copper, nickel and other precious metals mining in Minnesota,

Who wanted this fool of a governor to be Vice President of the US? Mistress Kamala! Thank God he did not become Vice President!

"Minnesota Gov. Tim Walz issued a sweeping executive order Tuesday that aims to prevent the mining of copper, nickel and other precious metals within the watershed of the Boundary Waters Canoe Area Wilderness in northeast Minnesota. ..."

‘King’ Walz bans copper mining in Minnesota, crippling attempts to de-carbonize the economy



Official photo of Governor Walz (Source)


The Fight for Afghanistan Isn’t Over

When will there ever be peace and prosperity again in Afghanistan?

"The modern history of war in Afghanistan spans over four decades of foreign intervention and internal civil conflict, beginning with the 1979 Soviet invasion [ending in 1989], transitioning through civil war [1989-2001] and the rise of the Taliban, and concluding with the 2001–2021 U.S.-led war." (Google Search)

The Fight for Afghanistan Isn’t Over "As armed opposition groups intensify attacks amid Taliban divisions, Lt. Gen. Sami Sadat explains in an exclusive interview why his forces have begun combat operations—and what comes next."

The Wolf Solar Grand Minimum roughly between 1270 and 1350 CE and of other grand solar minimums and grand solar cycles

Here is another reason why the global warming is a hoax and why climate change is a religion

Anthropocene greenhouse gases is an obscene explanation! What has probably more influence on climate on Earth when comparing trace gases and varying solar activity? Varying solar activity!

Let's not forget that the world population also increased tremendously over the past several centuries from about 1 billion around 1800 AD/CE to now about 9 billion (aka as the Population Bomb since 1968). Of course, so many humans and their activities largely concentrated in urban areas contribute to warming (e.g. urban heat island effect). However, world population growth might be at an inflection point.

Much more likely are variations in solar activity and solar cycles over short and long term periods that cause warming and cooling periods on Earth than trace gases in the atmosphere! We know for a long time about the 11 year solar activity cycle, but most likely there are other, yet to be discovered cycles like the grand solar cycle.

Grand solar minimums is the missing link I was looking for to possibly explain changes of extended warming to cooling climate periods.

Thanks to the incessant daily climate change demagoguery, the effect of solar activity on Earth climate is heavily suppressed, avoided and omitted! 

"The Wolf Solar Minimum is a grand solar minimum—a prolonged period of sharply reduced sunspot activity and magnetic output on the Sun—that lasted roughly from 1270 to 1350." (Google Search)

This Wolf Solar Minimum roughly coincides with the end of the Medieval Warm Period from about 950 AD/CE to 1250 AD/CE (not medieval climate anomaly) or it falls between the MWP and the Little Ice Age from about 1400 AD/CE to 1850 AD/CE. Or in other words, we are currently in another, modern warm period!

"Major historical grand solar minima identified in solar physics include the following:
Homeric minimum: ~750 BC – 400 BC
Oort minimum: 1040 – 1080
Wolf minimum: 1280 – 1350
Spörer Minimum: 1450 – 1550
Maunder Minimum: 1645 – 1715
Dalton Minimum: 1790 – 1820
Modern Minimum: 2020 – 2053" (Google Search)

From the abstract (1):
"In this editorial I will demonstrate with newly discovered solar activity proxy-magnetic field that the Sun has entered into the modern Grand Solar Minimum (2020–2053) that will lead to a significant reduction of solar magnetic field and activity like during Maunder minimum leading to noticeable reduction of terrestrial temperature. ..."

From the abstract (2):
"Recent progress in undersatanding a role of the solar background magnetic field in defining solar activity is presented using eigen vectors derived with Principle Compnent Analysis.
This approach revealed a presence of not only 11 year solar cycles but also of grand solar cycles with duration of 330-380 years.
We demonstrated that these grand cycles are formed by the interferences of two magnetic waves produced by solar dynamo with dipole magnetic field in two layers of the solar interior with close but not equal frequencies.
These grand cycles are always separated by grand solar minima (GSMs) similar to Maunder minimum type, with the modern GSM started in 2020 and to last until 2053.
This GSM leads to a reduction of solar irradiance by about 0.22% from the modern level and a decrease of the average terrestrial temperature by about 1.0C in the cycle 26.
The reduction of a terrestrial temperature can have important implications for different parts of the planet on growing vegetation, agriculture, food supplies and heating needs in both Northern and Southern hemispheres."

Modern Grand Solar Minimum will lead to terrestrial cooling (1, open access)

Modern grand solar minimum and its impact on the terrestrial environment (2, open access?)


Figure 3. Solar activity (summary) curve restored for 1200–3300 AD



Figure 4.
Top plot: restored total solar irradiance from 1600 until 2014 [Notice the dip around 1812 AD. This when Napoleon tried and failed to conquer Moscow due to an extremely cold winter.]
Bottom plot: Central England temperatures (CET) recorded continuously since 1658. Blue areas are reoccurring cool periods; red areas are warm periods. All times of solar minima were coincident with cool periods in central England.



Why immune responses to vaccines vary from person to person and how to predict a vaccine response before vaccination

Good news! A still open question how much of the humoral immune response is inherited and how much is due to lifetime training of the immune system of an individual.

"... In blood samples from more than 4,000 people, ASU researchers and their colleagues measured antibodies against 185 antigens—targets recognized by the immune system, including those from common viruses and bacteria as well as targets associated with autoimmune diseases.

They then used artificial intelligence to analyze patterns in samples collected before and after COVID-19 vaccination, identifying antibody signatures that helped distinguish strong vaccine responders from weak ones.

The research opens a possible path toward more personalized vaccination strategies.

"What our study found is that certain biomarkers, when analyzed with AI, can predict who is likely to respond well to a vaccine, even before they receive it. This suggests that some people may be more immune-ready than others," ..."

From the highlights and abstract:
"Highlights
Pre-existing antibodies to common microbes predict new vaccine response robustness
• These sentinel antibodies are stable markers of humoral immune readiness
AI models use global antibody profiles to stratify high and low vaccine responders
Blunted vaccine responses occur in both immunosuppressed and healthy individuals

Summary
Predicting which individuals will mount poor antibody responses before vaccination could improve personalized vaccination strategies.
Here, we conducted a national longitudinal study of humoral immune responses to 185 antigens, including SARS-CoV-2 (n = 3), common microbial pathogens (n = 157), and autoantigens (n = 25), in 1,644 immunosuppressed patients and 2,445 healthy individuals before and after COVID-19 vaccination.
Although blunted COVID-19 vaccine responses were more frequent in solid organ transplant recipients and individuals with multiple myeloma, autoimmune disease, inflammatory bowel disease, and human immunodeficiency virus, responses were highly heterogeneous within every cohort, and approximately 5%–6% of healthy individuals also mounted weak responses.
Pre-existing antibodies to common microbes, including Staphylococcus aureus, respiratory syncytial virus, and human respirovirus 3, consistently predicted post-vaccination antibody responses in both healthy and immunosuppressed populations.
These broadly prevalent antimicrobial antibodies represent sentinel antibodies that may serve as biomarkers of system-level humoral immune competence.
Using global antimicrobial antibody profiles, we developed a deep-learning predictive model that stratified individuals according to their likelihood of mounting blunted vaccine responses.
Together, these findings identify pre-existing antimicrobial antibody profiles as scalable biomarkers of humoral immune responsiveness and provide a framework for predicting vaccine responses before immunization."

Why immune responses to vaccines vary from person to person

Why immune responses to vaccines vary from person to person (original news release) "Study finds past immune encounters may predict future vaccine response"


Graphical abstract


Figure 2 The multiplexed humoral immune profiling of 8,687 individual samples among seven cohorts


Figure 7 Pre-existing antimicrobial antibody profiles predict healthy individuals with low vaccine response to COVID-19 booster


Robots learn new skills from a single video—in just 29 seconds

This seems to be an interesting new Chinese paper on robotics!

Did these researchers successfully overcome catastrophic learning of previously learned skills?

"... Researchers ... recently developed HOST (Human-to-robot One-Shot Skill AcquisiTion), a new framework that could allow robots to acquire new skills faster and more efficiently. Their proposed learning approach ... allows a robot to acquire a new skill from a single video showing a human demonstration without compromising previously acquired abilities. ..."

"...
Highlights
  • Inference-time skill acquisition: one human video, no fine-tuning, and no parameter update.
  • Fast acquisition: 29 seconds per novel skill on average, including recording the demonstration.
  • Broad real-robot evaluation: acquires executable skills across 50 novel manipulation tasks, each evaluated over 20 trials.
  • Strong novel-task performance: achieves 62% average success on the task subset used for baseline comparisons.
  • Data and time efficiency: 50 times fewer demonstrations and 507 times faster acquisition than the strongest task-specific fine-tuning baseline evaluated in the paper.
  • Skill retention: new skills are supplied through external video context rather than written into the shared policy weights.
  • Robust execution: evaluated under lighting changes, unseen objects, scene replacement, and human disturbances during execution.
..."

From the abstract:
"The ability to acquire skills rapidly and effortlessly while retaining those already mastered is essential for robots. However, current methods still rely on a cumbersome training-time loop that is costly and slow, while eroding skills already mastered.
In this paper, we introduce HOST (Human-to-robot One-Shot Skill AcquisiTion), a framework that enables a robot to acquire skills in seconds from a single human video while retaining previously mastered skills.
HOST resolves skill acquisition through a cascade of self-grounded prediction.
It first estimates the robot's progress within the demonstrated task, then translates the upcoming progression into the robot's own future observations, and finally derives actions from these predicted observations.
This cascade is trained on targets coupled to the video demonstration, obtained by mapping the robot trajectory and the video demonstration onto a shared task progress manifold, then redefining each target to align with the future progression of the video.
HOST thereby enables the robot to actively follow the demonstrated procedure and adapt it to the robot's embodiment.
HOST acquires novel skills at inference time from a single human video in an average of 29 seconds and achieves a 62% average success rate. It exceeds the zero-shot baseline by 45% while retaining previously mastered skills.
HOST even exceeds the baseline fine-tuned on 50 robot demonstrations per task while requiring 50 times fewer demonstrations and acquiring each skill 507 times faster. ..."

Robots learn new skills from a single video—in just 29 seconds

Why do we get sleepy? How neurons control sleep drive

Amazing stuff!

"... researchers from Beth Israel Deaconess Medical Center and Auburn University, have now identified specific neurons that are crucial for this balanced relationship between sleep and wakefulness.
"We have identified neuronal populations that monitor prolonged wakefulness and actively promote sleep," ... "This is an important missing piece of the puzzle in understanding why we become sleepy." ...

This highlighted specific brain areas that reflected time spent awake. Within one of these regions, they further identified two distinct neuronal populations that influence sleep drive: GABAergic and serotonergic neurons in the brainstem.
The activation of both neuronal populations increased the longer the animals stayed awake and declined again after sleep onset. ..."

From the abstract:
"Prolonged wakefulness increases sleep drive and is normally compensated for by increased sleep. This homeostatic regulation of sleep shapes our lives profoundly, but the underlying neural circuit mechanisms remain poorly understood.
Here, we identify wake-activated neurons that regulate sleep drive in mice, using whole-brain activity mapping, targeted neuronal manipulations and electrophysiology.
By comparing whole-brain responses to sleep deprivation, recovery sleep and circadian behaviour, we identify the anterior medial preoptic area and the median raphe as candidate regions that encode sleep deficit. Activating sleep-deprivation-responsive cells in these regions induces increases in sleep duration and intensity that resemble recovery sleep. Conversely, inhibiting deprivation-responsive cells reduces sleep and abolishes the increased sleep propensity usually observed during deprivation.
Neurons in the median raphe that are responsive to sleep deprivation project to subcortical sleep-associated regions and act through the preoptic hypothalamus. These deprivation-sensitive cells include serotonergic neurons and a distinct population of GABAergic neurons, whose intrinsic excitability increases during sleep deprivation.
Co-activation of GABAergic and serotonergic neurons synergistically promotes sleep, whereas 
co-inhibition chronically decreases sleep by nearly 70%.
Remarkably, most mice survive despite this marked reduction in sleep, without the compensatory increases in sleep drive or the behavioural deficits typically associated with severe sleep deprivation.
Together, these results define neuronal populations that are activated during wakefulness and are crucial for sleep drive."

Why do we get sleepy? How neurons control sleep drive

Why do we get sleepy? How neurons control sleep drive (original news release) "Why does staying awake inevitably make us sleepy? Researchers ... have identified neuronal populations in the brain that become activated during prolonged wakefulness and are crucial for sleep drive. Their findings provide new insights on how the brain generates the need for sleep."


Sleep-promoting neurons (green) and recently activated neurons (magenta) in the mouse brain.


Fig. 1: Mapping of whole-brain activity reveals correlates of sleep deprivation and recovery.


Fig. 2: Deprivation-TRAP cells promote NREM sleep and slow-wave activity.


Scientists unveil more than 600 new tissue models of human cancer including over 150 models of rare cancers

Amazing stuff! Cancer is history (soon)!

"... developed nearly 700 new cancer models, derived from patient tumors, which they hope will aid in drug development. 

These cells, which represent 25 different types of cancer, are now available for cancer researchers around the world to use. ..."

From the abstract:
"The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models. However, existing collections represent only a fraction of the diversity observed in human cancer. Recent technologies have enabled efficient in vitro model derivation (for example, tumour organoids). However, whether these maintain essential properties of patient tumours during long-term expansion has not been systematically investigated.
Here we present results of a large-scale international programme—the Human Cancer Models Initiative—which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses. The resource provides 522 models with comprehensive clinical data, 153 models of rare cancers and 71 models from participants with non-European ancestry. Analyses of 421 matched tumour–model pairs reveal high genetic (97.8%) and epigenetic (95%) concordance and define correlates of model discordance. Single-nucleus RNA sequencing of tumour–model pairs reveals subsets of models in which culture conditions significantly influence cell states.
Finally, we characterize model preservation of extrachromosomal DNA and post-treatment mutational signatures to provide opportunities to study therapeutic resistance.
This model repository is being made available to the community—including multimodal molecular profiling, clinical information and integrative software tools—thus providing a valuable resource for preclinical investigation of cancer pathogenesis and treatment response."

Scientists unveil more than 600 new tissue models of human cancer | MIT News | Massachusetts Institute of Technology "Derived from patient tumor samples and available to researchers around the world, the cells will aid the development of new cancer treatments."



Fig. 1: Overview of the HCMI resource and clinical demographics.


Fig. 3: Transcriptional and epigenetic concordance between models and matched tumours.


Forensic Psychiatrists on both sides agree the mother heard voices the day she killed her three children. Really!

How is that even possible? Seems to be junk headline! The forensic psychiatrists did not agree, they just heard the same story from the killer.

What did the husband know and what did he do about it?

"Forensic psychiatrists for both the defense and prosecution agree that Duxbury mother Lindsay Clancy was hearing voices on the day she strangled her three children but disagree on whether that makes her culpable for their murders.

Her uttering “Go to God” as she killed her children, one expert argued, suggests the mom knew what she was doing was wrong. ..."

"... [forensic psychiatrist Dr. Avram Mack] said Clancy recounted the killings to him, saying she heard a loud male voice telling her to kill the children so she could kill herself. She recalled strangling the children and saying "go to God" as she did so, he told jurors. ..."

Psychiatrists agree Lindsay Clancy heard voices the day she killed her children: 'Go to God' "The defense rests its case that she is not criminally responsible"

Who Is Natalie Harp? The Woman Always Beside President Trump with Palki Sharma

Anything wrong with her being a close confidant/aide of President Trump? So far the news coverage of Ms. Harp seems to be rather hot air!

Who Is Natalie Harp? The Woman Always Beside Trump | The Palki Sharma Show | India Global Review - YouTube


Friday, August 21, 2026

Calicut: A day of food in Kerala's culinary capital

Bon appetit!

(238) Calicut: A day of food in Kerala's culinary capital | BBC News India - YouTube


Khatia Buniatishvili plays Liebestraum No. 3 from Franz Liszt | Verbier Festival 2011

Enjoy!

(239) Khatia Buniatishvili plays Liebestraum No. 3 from Franz Liszt | Verbier Festival 2011 - YouTube


Prince - Hot Thing (Live - 'Sign O' The Times' - 1987)

Enjoy!

(238) Prince - Hot Thing (Live - 'Sign O' The Times' - 1987) - YouTube


Prince - Musicology (Official Music Video)

Enjoy!

(238) Prince - Musicology (Official Music Video) - YouTube


Prince - Nothing Compares 2 U (Official Video)

Enjoy!

(238) Prince - Nothing Compares 2 U (Official Video) - YouTube


Turkey Issues Arrest Warrant for Israel's Netanyahu Over 'Gaza Genocide'. Really!

Osman Sultan Erdogan (age 72, president of Turkey since 2014) is becoming more and more erratic! And Turkey is still a NATO member!

(236) Turkey Issues Arrest Warrant for Israel's Netanyahu Over 'Gaza Genocide' | Vantage on Firstpost - YouTube


Bank Withdrawals Surge: Is Russia Headed for a Banking Crisis?

Good news! Perhaps, there is a slow bank run going on in Russia! Make Putin the Terrible sweat and have nightmares!

(234) Withdrawals Surge: Is Russia Headed for a Banking Crisis? - YouTube







Texas Governor Greg Abbott asks US Department of Justice to investigate accommodations for Muslim foot washing at two major airports

Food for thought! When doe religious accommodations go too far?

Why does the airport have to provide this and not a Muslim organisation/mosque e.g. by renting a space on the airport for this purpose?

"Gov. Greg Abbott is escalating his fight against foot-washing stations used by Muslim passengers at Texas’ biggest airports, requesting on Friday that the U.S. Department of Justice to investigate the matter. ...

Abbott threatened last week to pull state funding from Dallas-Fort Worth International Airport and George Bush Intercontinental Airport in Houston over their ablution stations, saying they amounted to religious discrimination. The stations are used by Muslim passengers who perform ritual washings before their daily prayers. ..."

Greg Abbott asks DOJ to investigate Muslim airport accommodations

Engineers connect bacteria to create living transistors

Amazing stuff! Are we getting closer to artificial biological intelligence? You bet!

The human brain is a lot more energy efficient than machine learning & artificial intelligence. The human brain does not need a voracious water and energy consuming data center!

"MIT researchers have engineered bacteria that can function as transistors, allowing the team to create living “circuit boards” that can be printed onto a growth medium in a Petri dish. ...

The research team designed two different transistors, along with three bacterial strains that relay information between the transistors, giving them the building blocks they need to design nearly any type of circuit. In a new study, they used these cells to create circuits that can add two or three inputs, or send one input to a specific location in the circuit. ..."

From the abstract:
"The multicellular forms and functions seen in biology are controlled by cellular communication and collective computation.
Reprogramming natural systems is difficult because they comprise many signaling molecules connecting a web of regulatory networks within cells.
Here we apply principles from pass transistor logic (PTL) to design bacteria that can be easily reconfigured to perform computations on a solid surface. Strains of Pantoea agglomerans were built to encode two transistors (N-type and P-type) whose inputs and outputs are small molecules. They are connected by three relay strains that convert molecular diffusion to unidirectional flow.
To build circuits, an acoustic liquid handler prints patterns of these five strains on a surface.
By changing the pattern, not requiring any genetic changes, different operations are implemented, including multi-input multioutput logic, demultiplexor, half-adder and full-adder.
This work demonstrates that only five cell types, each encoding a simple operation, can be scaled to create complex computational operations."

MIT engineers connect bacteria to create living transistors | MIT News | Massachusetts Institute of Technology "By wiring together colonies of these bacteria, the researchers built circuits that can perform complicated calculations."





President Trump's Smart Move to Cut domestic Nonprofit Funding

Recommendable! Probably, federal government funding of nonprofits is way too lavish!

In general, it should be left mostly to the private sector to fund non-profits!

How much of it is vote buying and/or government funding of partisan propaganda?

"In fiscal year 2025 the federal government obligated $36.3B in grants directly to 501(c)(3) charities that are not universities or hospitals — down from $43.5B in FY2024, a 16.5% decline ..."

"... But the question is: What obligation does the federal government have to support such groups, and what would happen if these groups had to rely more on private donations for their operations? ...

While the Chronicle refers to the problem of losing federal support and instead being forced to rely on “donors whose interests can be fickle,” those donors are definitely looking for some bang for their buck. And yes, the donors may decide to withdraw funds from organizations that are not accomplishing what they want. But maybe this will force organizations to be more responsive to a wider audience. ...

At least 30 percent of nonprofits receive government grants, totaling $300 billion annually, according to a Candid analysis. That’s almost triple the amount that private foundations give to the same groups. ...

The depth of these entanglements becomes apparent on the rare occasions when the relationships break down. In 2024, the MacArthur Foundation withheld a grant of $625,000 from the San Francisco District Attorney’s Office until the office showed that it was “fully committed to the goals and strategies” of criminal-justice reform. [What! How is that even possible!] ..."

Trump's Smart Move to Cut Nonprofit Funding | American Enterprise Institute - AEI

What happened to federal grants to charities in FY2025? (This report provides annual data only for only two years, i.e. 2024 & 2025. This is lousy and deceptive!)

Federal Grants to Everyday Charities Fell 38% in Trump's First Months – Chronicle of Philanthropy (This report provides monthly data for only for two years, i.e. 2024 & 2025. This is lousy and deceptive!)

How reliant are nonprofits on government grants? "Delve into data to learn how many nonprofits rely on government grants—including which types of organizations and U.S. states receive them most–and discover what a potential freeze of federal funding may mean for the sector as a whole."