Showing posts with label sense of taste. Show all posts
Showing posts with label sense of taste. Show all posts

Wednesday, October 29, 2025

An artificial tongue for spiciness using skim milk powder

"Variety's the very spice of life, That gives it all its flavor!" (from a poem by William Cowper's 1785)

"... Scientists have previously developed artificial tongues that measure sweet and umami flavors, so researchers wanted to alter the technology for spicy foods by using the milk protein casein, which binds to capsaicin, the active compound in spicy peppers. They added skim milk powder to a flexible, opaque, tongue-shaped gel that conducted an electrical current; when the technology touched capsaicin, as well as pungent compounds in garlic, onion, horseradish, and ginger, the current changed and signaled their presence.

To validate their fake tongue against real ones, the researchers exposed their gel and a panel of taste testers to eight peppers and eight spicy foods. The tongue’s electrical responses matched the taste testers’ spiciness rankings and measured capsaicin concentrations from undetectable-by-humans to painful. ..."

"... So, researchers made an artificial tongue to quickly detect spiciness. Inspired by milk’s casein proteins, which bind to capsaicin and relieve the burn of spicy foods, the researchers incorporated milk powder into a gel sensor. The prototype, reported in ACS Sensors, detected capsaicin and pungent-flavored compounds (like those behind garlic’s zing) in various foods. ...

As a proof-of-concept, the researchers tested eight pepper types and eight spicy foods (including several hot sauces) on the artificial tongue and measured how spicy they were by changes in electrical current. A panel of taste testers rated the spiciness of the same items. Results from the artificial tongue and the tasting panel matched well. ..."

From the abstract:
"Artificial tongues have been extensively studied to detect the five basic tastes like humans. Spiciness, or pungency, is essential for food selection for both humans and animals. However, it is challenging to fully mimic human tongue-like performance for spicy taste.
Inspired by the fact that milk can relieve the pungent taste on the tongue, we introduced a soft gel-based artificial tongue as a flexible chemiresistive sensor for pungency detection.
When exposed to pungent compounds, it leads to the formation of hydrophobic complexes and conformational changes that decrease the ionic conductivity. The artificial tongue enables pungent compounds to be detected over a wide range (0.0001–1 wt %) with high sensitivity (0.259 wt %–1) and fast response times (<10 s).
Moreover, our artificial tongue can detect the pungency degree in a variety of spicy foods and condiments with intertranslatable ionic currents. Our work could enable both pungent compound detection and spicy sensation estimation, making a powerful platform for future applications involving movable humanoid robots and portable spicy taste monitoring devices."

ScienceAdviser


Wednesday, May 07, 2025

Investigator Charles Zuker and his team explore How We Taste Sweetness

Good news! That is funny! Zucker is the German word for sugar! Sometimes a name presents a calling (not to be confused with name calling). 😊

"... have unveiled the structure of the human sweet receptor, adding fundamental insights into taste detection and our understanding of the taste system, and paving the way for modern-day confectioners to reduce the amount of sugar in consumer products – all without sacrificing sweetness. ...

In 2001, Zuker’s laboratory discovered the genes that encode the sweet receptor. When we enjoy our favorite candies and desserts, these foods taste sweet solely because they activate this receptor.  ...

to cut back on the amount of sugar and calories in products, food and beverage makers could simply use less sugar and add a modulator to their product ..."

From the highlights and abstract:
"Highlights
• Two GPCR subunits assemble to recognize sweet ligands
• The TAS1R2 subunit binds the ligands and couples to the G protein
• A common binding pocket recognizes sucralose and aspartame
• 3D variability analysis shows coordinated structural changes between the subunits

Summary
In humans, the detection and ultimately the perception of sweetness begin in the oral cavity, where taste receptor cells (TRCs) dedicated to sweet-sensing interact with sugars, artificial sweeteners, and other sweet-tasting chemicals.
Human sweet TRCs express on their cell surface a sweet receptor that initiates the cascade of signaling events responsible for our strong attraction to sweet stimuli. Here, we describe the cryo-electron microscopy (cryo-EM) structure of the human sweet receptor bound to two of the most widely used artificial sweeteners—sucralose and aspartame.
Our results reveal the structural basis for sweet detection, provide insights into how a single receptor mediates all our responses to such a wide range of sweet-tasting compounds, and open up unique possibilities for designing a generation of taste modulators informed by the structure of the human receptor."

Scientists Unveil the Structure of the Receptor Responsible for How We Taste Sweetness | HHMI

The structure of human sweetness (open access)

Graphical abstract

Figure S2 Cryo-EM data processing workflow, related to STAR Methods



Charles Zuker


Monday, September 29, 2014

Hummingbirds Not Fooled By Sugar Substitutes In Diet Sodas

Posted: 9/29/2014


Trigger




Neither am I fooled by sugar substitutes! :-)


Imagine


“Their ;hummingbirds] hearts beat 20 times a second and their tongues dart 17 times a second as they slurp from a feeding station.

It takes only three quick licks to reject water when they expect nectar. The birds pull back their beaks, shake their heads, and spit out the tasteless liquid.”