Metastatic circulating tumor cells from breast cancer spread when women sleep

Good news! Cancer is history (soon)! I hope, this will not cause women to have insomnia. Melatonin is also implicated.

By the way, yesterday I have here exposed the perverse gender identity ideology of Nature journal, because women cannot have breast cancer, only people can, but women can be scientists, because they are vulnerable and marginalized.

"... Now, a study finds that for people [women] with breast cancer, these rogue cells — called circulating tumour cells, or CTCs — are more likely to jump into the blood at night than during the day. ...
The research community has been discussing for decades how the body’s circadian rhythm influences cancer. With this study, it has become clear that “tumours wake up when patients are sleeping”... It’s a “step forward” in understanding metastasis ..."

From the abstract:

"The metastatic spread of cancer is achieved by the haematogenous dissemination of circulating tumour cells (CTCs). Generally, however, the temporal dynamics that dictate the generation of metastasis-competent CTCs are largely uncharacterized, and it is often assumed that CTCs are constantly shed from growing tumours or are shed as a consequence of mechanical insults. Here we observe a striking and unexpected pattern of CTC generation dynamics in both patients with breast cancer and mouse models, highlighting that most spontaneous CTC intravasation events occur during sleep. Further, we demonstrate that rest-phase CTCs are highly prone to metastasize, whereas CTCs generated during the active phase are devoid of metastatic ability. Mechanistically, single-cell RNA sequencing analysis of CTCs reveals a marked upregulation of mitotic genes exclusively during the rest phase in both patients and mouse models, enabling metastasis proficiency. Systemically, we find that key circadian rhythm hormones such as melatonin, testosterone and glucocorticoids dictate CTC generation dynamics, and as a consequence, that insulin directly promotes tumour cell proliferation in vivo, yet in a time-dependent manner. ..."

These cancer cells wake up when people sleep Researchers make ‘striking’ discovery that breast cancer cells are more likely to jump into the blood when people are resting.

The metastatic spread of breast cancer accelerates during sleep (no public access)