Good news! Cancer is history (soon)!
This seems to be a major advance, because you do not need to personalize this vaccine!
"... developed a novel cancer vaccine that targets this process by inducing the body to manufacture antibodies against the “kill me” proteins. This approach effectively locks them in place on cancer cells’ surfaces, preventing the cells from destroying them. That, in turn, makes them available to trigger killing responses from both T and NK cells. ...
The team demonstrated the vaccine’s usefulness in mice with melanoma and triple-negative breast cancer, both of which frequently metastasize even after a patient has surgery to remove existing tumors. They surgically removed the animals’ tumors, then administered the vaccine, and saw that the rate of metastasis was greatly reduced. When they re-challenged some of the vaccinated animals with cancerous tumors four months later, none of them developed the disease. ...
The vast majority of other cancer vaccines must be personalized for each individual patient because they are designed to target specific molecules on the surface of a patient’s tumor. This vaccine, in contrast, can be used “off-the-shelf” without the need for a lengthy and expensive personalization process, because the “kill me” protein is present in most cell types. ..."
The team demonstrated the vaccine’s usefulness in mice with melanoma and triple-negative breast cancer, both of which frequently metastasize even after a patient has surgery to remove existing tumors. They surgically removed the animals’ tumors, then administered the vaccine, and saw that the rate of metastasis was greatly reduced. When they re-challenged some of the vaccinated animals with cancerous tumors four months later, none of them developed the disease. ...
The vast majority of other cancer vaccines must be personalized for each individual patient because they are designed to target specific molecules on the surface of a patient’s tumor. This vaccine, in contrast, can be used “off-the-shelf” without the need for a lengthy and expensive personalization process, because the “kill me” protein is present in most cell types. ..."
From the abstract:
"Most cancer vaccines target peptide antigens, necessitating personalization owing to the vast inter-individual diversity in major histocompatibility complex (MHC) molecules that present peptides to T cells. Furthermore, tumours frequently escape T cell-mediated immunity through mechanisms that interfere with peptide presentation. Here we report a cancer vaccine that induces a coordinated attack by diverse T cell and natural killer (NK) cell populations. The vaccine targets the MICA and MICB (MICA/B) stress proteins expressed by many human cancers as a result of DNA damage. ... The vaccine is also efficacious in a clinically important setting: immunization following surgical removal of primary, highly metastatic tumours inhibits the later outgrowth of metastases. This vaccine design enables protective immunity even against tumours with common escape mutations."
A vaccine targeting resistant tumours by dual T cell plus NK cell attack (no public access)
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