Good news! I toast to that! 😊🍸
"Scientists found that giving mice a shot of a hormone called FGF21, which both mice and humans naturally produce in their livers in response to alcohol, helped mice recover from a drunken stupor, New Scientist reports. ...
But drunk mice that got a shot of FGF21 quickly regained their coordination and sobered up faster than their still inebriated counterparts. Next, the researchers learned that the hormone influenced a group of neurons in the brain that express a chemical neurotransmitter called noradrenaline. ... which could potentially be used to treat alcohol poisoning."
But drunk mice that got a shot of FGF21 quickly regained their coordination and sobered up faster than their still inebriated counterparts. Next, the researchers learned that the hormone influenced a group of neurons in the brain that express a chemical neurotransmitter called noradrenaline. ... which could potentially be used to treat alcohol poisoning."
From the highlights and abstract:
"Highlights
• Hormone FGF21 counteracts alcohol-induced loss of consciousness and coordination
• Pharmacologic FGF21 accelerates recovery from alcohol-induced intoxication
• FGF21 exerts its sobering effect by activating the noradrenergic nervous system
Summary
Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the detrimental effects of inebriation. In this report, we show that the hormone FGF21, which is strongly induced by ethanol in murine and human liver, stimulates arousal from intoxication without changing ethanol catabolism. Mice lacking FGF21 take longer than wild-type littermates to recover their righting reflex and balance following ethanol exposure. Conversely, pharmacologic FGF21 administration reduces the time needed for mice to recover from ethanol-induced unconsciousness and ataxia. FGF21 did not counteract sedation caused by ketamine, diazepam, or pentobarbital, indicating specificity for ethanol. FGF21 mediates its anti-intoxicant effects by directly activating noradrenergic neurons in the locus coeruleus region, which regulates arousal and alertness. These results suggest that this FGF21 liver-brain pathway evolved to protect against ethanol-induced intoxication and that it might be targeted pharmaceutically for treating acute alcohol poisoning."
Graphical abstract
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