New cancer treatment uses bacteria to the immune system to attack

Good news! Cancer is history (soon)! Sounds like a promising approach!

"... developing a novel way of knocking out tumors – by coating them in bacteria. ...

For NeoTX, ... identified and licensed a drug developed by the Swedish company Active Biotech called naptumomab estafenatox (NAP).

NAP is composed of two proteins: a genetically modified “superantigen” and an antibody that latches onto a tumor via a molecule called 5T4 found primarily on tumors.

A superantigen is a bacterial derivative that elicits a strong antibacterial immune response. NeoTX calls its technology “Tumor-Targeted Superantigen” or TTS.

Once NAP’s 5T4 antibody has attached itself to a tumor, the superantigen “reprograms” the immune system to mount an antibacterial response against the bacteria as well as the tumor. ...
The T-cells identify the bacteria-coated tumors, then start to create an army of cells primed to attack any superantigens they find. ..."

New cancer treatment fools the immune system to attack - ISRAEL21c NeoTX, whose team includes several Nobel laureates, is testing a cancer-fighting approach that uses bacteria to bait the immune system into an attack.

NeoTX announces successful first stage completion of its Phase 2a clinical trial of naptumomab estafenatox (NAP), in combination with docetaxel in advanced non-small cell lung cancer (NSCLC)