Antibody “master key” discovery could neutralize all COVID variants

Good news! Covid-19 is history! 

With charlatan and liar Fauci gone, perhaps we can finally return to science if there were not this lunatic German clone of Fauci, i.e. the Federal Minister of Health Lauterbach. 

In early July I blogged here about new antibodies that are effective against a wide range of coronaviruses and all SARS-CoV-2 variants.

"A new study published in Nature Communications has homed in on a part of the SARS-CoV-2 spike protein that seems to be shared across all known variants. The research also reveals an antibody fragment that can hypothetically block the virus from entering human cells, paving the way for future therapies to neutralize all COVID-19 variants.
The new research offers one of the most thorough investigations to date into the spike protein differences between a number of SARS-CoV-2 variants. Using cryo-electron microscopy the study zoomed in on spike proteins from Alpha, Beta, Gamma, Delta, Kappa, Epsilon, and Omicron (BA.1 and BA.2) variants. ...
The researchers discovered a certain part of the spike protein is conserved across all these variants. This spot, known as an epitope, is vulnerable to novel antibodies that could block the virus' ability to infect human cells. ..."

"... The paper further describes an antibody fragment called VH Ab6 that is able to attach to this site and neutralize each major variant. ..."

From the abstract:

"Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we describe an antibody fragment (VH ab6) that neutralizes all major variants including the recently emerged BA.1 and BA.2 Omicron subvariants, with a unique mode of binding revealed by cryo-EM studies. Further, we provide a comparative analysis of the mutational effects within previously emerged variant spikes and identify the structural role of mutations within the NTD and RBD in evading antibody neutralization. Our analysis shows that the highly mutated Gamma N-terminal domain exhibits considerable structural rearrangements, partially explaining its decreased neutralization by convalescent sera. Our results provide mechanistic insights into the structural, functional, and antigenic consequences of SARS-CoV-2 spike mutations and highlight a spike protein vulnerability that may be exploited to achieve broad protection against circulating variants."

Antibody “master key” discovery could neutralize all COVID variants

UBC researchers discover ‘weak spot’ across major COVID-19 variants

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization (open access)

Cryo-electron microscopy reveals how the VH Ab6 antibody fragment (red) attaches to the vulnerable site on the SARS-CoV-2 spike protein (grey) to block the virus from binding with the human ACE2 cell receptor (blue).