Don't worry about SARS-CoV-2/Covid-19 anymore! Better vaccines and treatments are being developed! See also my new post here about a different approach!
"Scientists ... have characterized 30 antibodies that recognize a wide range of coronaviruses—successfully blocking not only all the SARS-CoV-2 variants that were tested, but other, related viruses including SARS-CoV-1, which caused the original SARS outbreak with high mortality in 2003, one found only in bats and another from pangolins. The antibodies were all isolated from people with “hybrid immunity” who had been infected with SARS-CoV-2 and subsequently vaccinated against the virus.
The new details on the antibodies, published today in Nature Immunology, are a step toward the next generation of coronavirus vaccines, which may help ward off a broader swath of viruses than the current vaccines specific to SARS-CoV-2. ..."
From the abstract:
"... Here, we utilized a targeted donor selection strategy to isolate a large panel of human broadly neutralizing antibodies (bnAbs) to sarbecoviruses. Many of these bnAbs are remarkably effective in neutralizing a diversity of sarbecoviruses and against most SARS-CoV-2 VOCs, including the Omicron variant. Neutralization breadth is achieved by bnAb binding to epitopes on a relatively conserved face of the receptor-binding domain (RBD). Consistent with targeting of conserved sites, select RBD bnAbs exhibited protective efficacy against diverse SARS-like coronaviruses in a prophylaxis challenge model in vivo. These bnAbs provide new opportunities and choices for next-generation antibody prophylactic and therapeutic applications and provide a molecular basis for effective design of pan-sarbecovirus vaccines."
Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses (open access)
Fig. 4: Epitope specificities of sarbecovirus bnAbs.
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