Thursday, August 18, 2022

Deceased Donor kidney blood type converted to O in step towards universal organs

Good news! It appears, the specific research paper has not yet been published.

"... The team first tested the technique on pieces of human kidney tissue, before moving on to three full kidneys with blood type B. The process takes about six hours, and was found to reduce blood type antigens in the organs by over 90%. ..."

"The project, funded by charity Kidney Research UK, could increase the supply of kidneys available for transplant, particularly within ethnic minority groups who are less likely to be a match for the majority of donated kidneys. ...
used a normothermic perfusion machine – a device which connects with a human kidney to pass oxygenated blood through the organ to better preserve it for future use – to flush blood infused with an enzyme through the deceased kidney.
The enzyme acted like “molecular scissors” to remove the blood type markers that line the blood vessels of the kidney resulting in the organ being converted to the most common O type.  ..."

Donor kidney blood type converted in step towards universal organs

Cambridge researchers change donor kidney blood type Researchers have been able to alter the blood type of deceased donor kidneys using “molecular scissors”.
The discovery offers hope to ethnic minority patients who struggle to find suitable transplants.

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