Good news! Cancer is history!
"Drugs called immune checkpoint inhibitors have transformed treatment of many types of tumors, but metastatic lung cancer has proven more challenging: While these medications have significantly extended survival for some patients, most still do not respond or develop resistance quickly. Now a small proof-of-concept study published in Nature Medicine shows that a new form of immunotherapy using a patient’s own immune cells may bring about durable responses for some people with advanced non-small cell lung cancer (NSCLC). ..."
"... Of 13 evaluable patients, 3 had confirmed responses and 11 had reduction in tumor burden, with a median best change of 35%. Two patients achieved complete responses that were ongoing 1.5 years later. In exploratory analyses, we found T cells recognizing multiple types of cancer mutations were detected after TIL [tumor-infiltrating lymphocytes] treatment and were enriched in responding patients. Neoantigen-reactive T cell clonotypes increased and persisted in peripheral blood after treatment. Cell therapy with autologous TILs is generally safe and clinically active and may constitute a new treatment strategy in metastatic lung cancer."
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