Sunday, July 18, 2021

DeepMind’s AI for protein structure is coming to the masses

Good news! Google's many contributions over the years to AI are deep mind boggling!

"... Through an enormous experimental effort, the structures of around 100,000 unique proteins have been determined, but this represents a small fraction of the billions of known protein sequences. Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Predicting the 3-D structure that a protein will adopt based solely on its amino acid sequence, the structure prediction component of the ‘protein folding problem’, has been an important open research problem for more than 50 years. ...
Here we provide the first computational method that can regularly predict protein structures with atomic accuracy even where no similar structure is known. We validated an entirely redesigned version of our neural network-based model, AlphaFold, in the challenging 14th Critical Assessment of protein Structure Prediction (CASP14)15, demonstrating accuracy competitive with experiment in a majority of cases and greatly outperforming other methods. ..."

DeepMind’s AI for protein structure is coming to the masses Machine-learning systems from the company and from a rival academic group are now open source and freely accessible.

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