Recommendable! Good news! Sounds a bit nutty!
"... ‘Bacteria appear to use controlled self-poisoning with H2S to slow down their metabolism, preventing the antibiotics from using the bacteria’s energy production system to kill them,’ ..."
"... In one defense mechanism, tolerant bacteria, also called “persisters,” stop multiplying (proliferating), reducing their energy use (metabolism) to survive antibiotic treatment, but resuming growth when the treatment ends. Persisters are particularly abundant in biofilms, bacterial colonies that live in tough polymeric matrices, which further prevent their eradication. ...
In their prior work, the NYU Langone research team showed that H2S production is deployed against antibiotics by a wide variety of bacterial species, including two increasingly antibiotic-resistant pathogens prevalent in hospital-borne infections: Staphylococcus aureus and Pseudomonas aeruginosa. S. aureus is gram-positive, while Pseudomonas aeruginosa is gram-negative, with the differing organizations of their outer layers demonstrating that H2S production protects pathogens across the bacterial kingdom. Remarkably, the research team found that both species rely on the same enzyme, cystathionine γ-lyase (CSE), for the bulk of H2S production. Blocking its action would represent then a way to remove an important defense against antibiotics, but available CSE inhibitors have a low potency against bacterial CSE and a high probability of causing side effects in human tissue ..."
In their prior work, the NYU Langone research team showed that H2S production is deployed against antibiotics by a wide variety of bacterial species, including two increasingly antibiotic-resistant pathogens prevalent in hospital-borne infections: Staphylococcus aureus and Pseudomonas aeruginosa. S. aureus is gram-positive, while Pseudomonas aeruginosa is gram-negative, with the differing organizations of their outer layers demonstrating that H2S production protects pathogens across the bacterial kingdom. Remarkably, the research team found that both species rely on the same enzyme, cystathionine γ-lyase (CSE), for the bulk of H2S production. Blocking its action would represent then a way to remove an important defense against antibiotics, but available CSE inhibitors have a low potency against bacterial CSE and a high probability of causing side effects in human tissue ..."
"... Here we report an effective antimicrobial strategy targeting the bacterial hydrogen sulfide (H2S)–mediated defense system. We identified cystathionine γ-lyase (CSE) as the primary generator of H2S in two major human pathogens, Staphylococcus aureus and Pseudomonas aeruginosa, and discovered small molecules that inhibit bacterial CSE. These inhibitors potentiate bactericidal antibiotics against both pathogens in vitro and in mouse models of infection. CSE inhibitors also suppress bacterial tolerance, disrupting biofilm formation and substantially reducing the number of persister bacteria that survive antibiotic treatment. Our results establish bacterial H2S as a multifunctional defense factor and CSE as a drug target for versatile antibiotic enhancers. ..."
Researchers Discover Critical Role of Hydrogen Sulfide in Ability of Bacteria to Survive Antibiotics
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