Good news! It is long overdue that humanity defeats the age old nemesis tuberculosis!
"... Researchers at Tel Aviv University have demonstrated in laboratory mice that monoclonal antibodies can be substituted for antibiotics to hinder the growth of tuberculosis germs.
It’s estimated that around a quarter of the world’s population is infected by tuberculosis. ..."
"... In the present study, we explore B cell responses during ATB [active TB], while focusing on the immune-dominant antigen PstS1. We isolate and analyze a total of 85 monoclonal antibodies (mAbs) from one patient with elevated anti-PstS1 responses and find two antibodies, p4-36 and p4-163, from distinct clones that demonstrate inhibitory activity against both BCG and Mtb. Structural analysis reveals that the two antibodies are directed against two different epitopes on PstS1 and do not compete with one another. When administered prior to infection of Balb/c mice with Mtb, both antibodies cause a 50% reduction in lung bacterial burden. Our data show that both p4-36 and p4-163 exhibit antibacterial activity and provide the first proof of concept that protective antibody responses can be generated during the course of active tuberculosis disease ..."
Here is the referenced paper:
No comments:
Post a Comment