Monday, March 22, 2021

No uterus, no problem: Mouse embryos grown in bottles form organs and limbs

Want to bet in about 20-40 years women don't have to give birth anymore! I blogged here, here about it.

"Developmental biologists have devised a method for growing mouse embryos outside a uterus for longer than ever before, giving them an unprecedented view of how mammalian organs and limbs form—a process previously hidden inside a mother’s body. Researchers in Israel report today that the new system, which includes rotating bottles filled with nutrients, kept the mouse embryos alive from roughly day five of development until day 11, about halfway through the animals’ 20-day gestation. By that time the embryos have formed hind limbs and all their major organs. ..."

"... Histological, molecular, and single-cell RNA-seq analyses validate that the ex utero cultured embryos recapitulate in utero development precisely. This culture system is amenable to introducing a variety of embryonic perturbations and micro-manipulations that can be followed ex utero for up to six days. Establishment of a system to robustly grow normal mouse embryos ex utero from pre-gastrulation to advanced organogenesis represents a valuable tool to investigate embryogenesis, eliminating the uterine barrier to mechanistically interrogate post-implantation morphogenesis and tissue specification in mammals."

No uterus, no problem: Mouse embryos grown in bottles form organs and limbs | Science | AAAS

Here is the link to the preprint version of the underlying research paper:


Lab-Grown Mouse Embryos Form Limbs and Organs The embryos completed one-third of their total gestation outside of a uterus.



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