Very recommendable! This seems to make a lot of sense and it has great potential! Will my next flu shot be inhalable? I will not hold my breath! 😄
"Many viruses infect their hosts through mucosal surfaces such as the lining of the respiratory tract. ...
The researchers showed that they could induce a strong memory T cell response in the lungs of mice by giving them a vaccine modified to bind to a protein naturally present in mucus. This can help ferry the vaccine across mucosal barriers, such as the lining of the lungs. ...
In addition to protecting against pathogens that infect the lungs, these types of inhaled vaccines could also be used to treat cancer metastasizing to the lungs or even prevent cancer from developing in the first place ...
Most vaccines are given as an injection into the muscle tissue. However, most viral infections occur at mucosal surfaces such as the lungs and upper respiratory tract, reproductive tract, or gastrointestinal tract. ...
The researchers also tested a mucosal vaccine against cancer. In that case, they used a peptide found on melanoma cells to immunize mice. When the vaccinated mice were exposed to metastatic melanoma cells, T cells in the lungs were able to eliminate them. The researchers also showed that the vaccine could help to shrink existing lung tumors. ..."
The researchers showed that they could induce a strong memory T cell response in the lungs of mice by giving them a vaccine modified to bind to a protein naturally present in mucus. This can help ferry the vaccine across mucosal barriers, such as the lining of the lungs. ...
In addition to protecting against pathogens that infect the lungs, these types of inhaled vaccines could also be used to treat cancer metastasizing to the lungs or even prevent cancer from developing in the first place ...
Most vaccines are given as an injection into the muscle tissue. However, most viral infections occur at mucosal surfaces such as the lungs and upper respiratory tract, reproductive tract, or gastrointestinal tract. ...
the researchers attached an albumin-binding lipid tail to a peptide vaccine against the vaccinia virus. The vaccine also included a commonly used adjuvant called CpG, which helps to provoke a stronger immune response.
The vaccine was delivered intratracheally, which simulates inhalation exposure. The researchers found that this type of delivery generated a 25-fold increase in memory T cells in the mouse lungs, compared to injecting the albumin-modified vaccine into a muscle site far from the lungs. They also showed that when mice were exposed to the vaccinia virus months later, the intramuscular vaccine offered no protection, while all of the animals that received the vaccine intratracheally were protected. ...The researchers also tested a mucosal vaccine against cancer. In that case, they used a peptide found on melanoma cells to immunize mice. When the vaccinated mice were exposed to metastatic melanoma cells, T cells in the lungs were able to eliminate them. The researchers also showed that the vaccine could help to shrink existing lung tumors. ..."
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