Tuesday, March 16, 2021

Stress Response Protein Links Inflammatory Disease to Colon Cancer

Good advice: Live life with the least stress possible! Cancer is history!

"In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease. While the causal and clinical links are well established, molecular understanding of how chronic inflammation leads to the development of colon cancer is lacking. ...
We detect early changes in ECM [extracellular matrix] structure and composition, and report a crucial role for the transcriptional regulator heat shock factor 1 (HSF1) in orchestrating these events. Loss of HSF1 abrogates ECM assembly by colon fibroblasts in cell-culture, prevents inflammation-induced ECM remodeling in mice and inhibits progression to CAC. ..."

Stress Response Protein Links Inflammatory Disease to Colon Cancer

Here is the link to the underlying research paper:

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