Getting under the skin of psoriasis

Good news! Amazing stuff! This study combines two of the latest technologies!

"... an ionic liquid (IL) combination to successfully deliver a small interfering RNA (siRNA)-based treatment directly to the skin in a mouse model of psoriasis, significantly reducing levels of inflammatory cytokines and symptoms of psoriasis without systemic side effects. ..."

"... However, effective delivery of small interfering RNA (siRNA) into the skin is a substantial hurdle due to skin’s barrier function and poor stability of siRNA. Using ionic liquids as an enabling technology, we report on the effective delivery of NFKBIZ siRNA into the skin and its therapeutic efficacy in a psoriasis model. Treatment with IL-siRNA suppressed aberrant gene expression and resulted in down-regulation of psoriasis-related signals including TNF-α and IL-17A. These results provide a framework for a topical delivery platform for siRNA."

Getting under the skin of psoriasis Ionic-liquid-based technology delivers RNA therapeutic to locally block psoriasis-associated genes in mice

Here is the link to the research paper: Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations