Combination gene therapy treats multiple age-related diseases in mice

Towards healthy longevity! One of the implications of these stunning results is: Forecasts of the need for more medical care services and expenditures for elderly people can be relegated to the trash bin!
And this is only the beginning! We ain't seen nothing yet!

"In the Wyss study, a single administration of an adeno-associated virus (AAV)-based gene therapy, which delivered combinations of three longevity-associated genes to mice, dramatically improved or completely reversed multiple age-related diseases [heart failure, kidney failure, diabetes, and obesity], suggesting that a systems-level approach to treating such diseases could improve overall health and lifespan"

"FGF21 [gene] caused complete reversal of weight gain and Type 2 diabetes in obese, diabetic mice following a single gene therapy administration, and its combination with sTGFβR2 [gene] reduced kidney atrophy by 75 percent in mice with renal fibrosis. Heart function in mice with heart failure improved by 58 percent when they were given sTGFβR2 alone or in combination with either of the other two genes, showing that a combined therapeutic treatment of FGF21 and sTGFβR2 could successfully treat all four age-related conditions, therefore improving health and survival"

Combination gene therapy treats multiple age-related diseases in mice: Treatment increases healthspan in mice and could lead to increased longevity therapies



Researchers able to improve, reverse age-related diseases in mice – Harvard Gazette: Wyss Institute, Harvard Medical School study offers hope for single genetic treatment for multiple age-related ills.