CRISPR-Edited T Cells Used in Cancer Patients for the First Time in the US

Good news! Cancer is history! What a sophisticated, multi-pronged attack on cancer employing the immune system!



"... T cells from three cancer patients—two with multiple myeloma and one with sarcoma—through a blood draw, and genetically modified the cells’ DNA using CRISPR. They inserted a gene from a virus into the immune cells that causes the cells to target the protein NY-ESO-1, found on cancer cells, and deactivated three genes within the cells that could interfere with their cancer-fighting ability. Two of the gene edits inactivate TCRα and TCRβ, causing T cell receptors to be removed. Without the receptors, the the cells can more easily bind to cancer cells. The third edit disables PDCD1, a gene that can kill T cells.



The researchers then infused the cells back into the patients, who have since had no significant adverse effects after six months ..."



CRISPR-Edited T Cells Used in Cancer Patients for the First Time in the US | The Scientist Magazine®: CRISPR-Edited T Cells Used in Cancer Patients for the First Time in the US
The initial findings from a small clinical trial of patients with multiple myeloma or sarcoma suggest that gene-edited immunotherapy is safe.