Amazing stuff! However, this was only reported for a very narrowly defined population of mice. I am not sure why Nature journal highlighted this research.
You get another chance to gain weight again! Just kidding!
"The GLP-1 medication semaglutide (Ozempic, Wegovy) has anti-ageing properties, at least in mice, write gerontologists ... Older female mice that received semaglutide lived longer than those that didn’t receive the drug, and had better outcomes for inflammation, cellular senescence, and neurodegeneration outcomes. The treated mice also performed better on cognitive tests than untreated mice fed a strict diet, suggesting the drug has benefits that aren’t explained by calorie reduction alone."
From the abstract:
"Pharmacological glucagon-like peptide-1 receptor (GLP-1R) activation reduces food intake and is an effective therapy for type 2 diabetes and obesity.
The use of GLP-1 medicines has revealed pleiotropic beneficial effects beyond glucose and weight control but little is known about the underlying basis of the pleiotropic effects.
Here, treatment of 20-month-old female C57BL/6 mice with the GLP-1R agonist semaglutide for 3 months improved physiological function, attenuated hallmarks of ageing and modulated nutrient sensors and conserved genetic regulators of ageing. Continued treatment extended mouse lifespan.
These effects parallel key features of calorie restriction, a dietary intervention that slows ageing, extends lifespan and alleviates a wide spectrum of ageing-associated diseases.
In a longitudinal study in direct comparison to matched calorie restriction, semaglutide treatment preserved baseline function and recapitulated many functional benefits of calorie restriction by attenuating age-associated decline, while also producing improvements above baseline and more favourable trajectories than calorie restriction in exploratory drive, spatial memory and glucose control.
Together, these findings demonstrate that GLP-1R activation initiated late in life slows ageing and extends lifespan in female mice, supporting its function as a calorie restriction mimetic and providing a mechanistic framework that may help to explain its broad beneficial effects while revealing effects beyond those attributable to reduced calorie intake."
Weight-loss drug slows ageing in female mice (behind paywall) "In one inbred strain of laboratory mice, late-life treatment with a GLP-1 drug extends lifespan. This effect might be more than just a consequence of calorie restriction."
Fig. 1: GLP-1R activation late in life extends lifespan and improves physiological function.
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