Serious stuff! Cancer is history (soon)!
"... These viruses, bacteria and other microbes are the focus of a new paper published Monday in The Lancet Oncology that linked an estimated 2.3 million new cancer cases in 2024 — 12 per cent of all new cases — to these infectious agents.
A team of researchers at The International Agency for Research on Cancer (IARC), an arm of the World Health Organization, conducted the study. They found the largest number of cancer cases attributed to infections globally were caused by the bacterium Helicobacter pylori, which can increase the risk of stomach cancer and accounted for 760,000 cases, predominantly in eastern Asia. ...
For the first time, researchers linked even more cancers to infections, expanding their list to include 16 additional ones. ..."
From the abstract:
"Background
Infectious agents are an important preventable cause of cancer globally. To inform prevention efforts, we provide a comprehensive picture of cancer burden attributable to infections, including newly established, carcinogenic infectious agents and latest global cancer incidence estimates.
Methods
In this worldwide incidence analysis, we used data from the Global Cancer Observatory's Cancer Today (GLOBOCAN) database of cancer incidence in 2024 to estimate population-attributable fractions (PAFs), absolute numbers, and age-standardised incidence rates (ASIRs) of new cancer cases attributable to 12 infectious agents classified as Group 1 carcinogens by the IARC Monographs Programme:
Helicobacter pylori, human papillomavirus (HPV), hepatitis B (HBV) and hepatitis C viruses (HCV), Epstein–Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus, Schistosoma haematobium, human T-cell lymphotropic virus, Opisthorchis viverrini, Clonorchis sinensis, Merkel cell polyomavirus, and HIV. Estimates stratified by sex, country, and age group were aggregated by UN geographical subregion and World Bank income group.
Findings
An estimated 2·3 million new cancer cases were attributable to infections globally in 2024, which is equivalent to 12% of all cancer cases.
The largest number of cases was attributable to
H pylori (n=760 000, PAF 4%), followed by
HPV (n=750 000, 4%), HBV (n=360 000, 2%),
EBV (n=260 000, 1%), and
HCV (n=160 000, <1%).
The largest burden of infection-attributable cancer was in eastern Asia, with 990 000 cases (42% of the global total, ASIR 31·9 per 100 000 cases). ASIRs were also higher than the global average (22·7) in sub-Saharan Africa (28·5), central and eastern Europe (24·3), and southeastern Asia (23·1).
Focused analysis of EBV-attributable cancers revealed regional variation in the distribution of cancer types."
1 in 8 cancer cases worldwide is caused by infections, study suggests "Researchers estimate infections caused 2.3 million new cancer cases worldwide in 2024"
Figure 1 ASIR of infection-attributable cancers per 100 000 person-years in 2024 for the six infectious agents with the most attributable cases
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