Amazing stuff! It took only two years from preprint to publication! Caution irony!
"During sleep, consolidation of all types of memories is thought to be initiated by hippocampal replay of spatiotemporal context. However, whether the hippocampus is the driver of, and needed for, memory consolidation in all conditions remains a matter of debate.
Thompson et al. showed that the consolidation of procedural memory occurs in the striatum, without the involvement of the hippocampus. Bilateral hippocampal lesions did not affect memory consolidation, suggesting that the hippocampus is not necessary for triggering procedural memory consolidation."
From the abstract:
"Sleep is crucial for consolidating all forms of memory and a core mechanism underlying this process is offline replay.
Current models propose that replay originates in the hippocampus and triggers reactivation across cortical and subcortical networks. However, conflicting evidence about the role of the hippocampus in offline consolidation of nondeclarative memories raises the question of whether hippocampal replay drives their consolidation.
Here we show that replay occurs in the dorsal striatum during offline consolidation of a procedural memory in mice, independently of the hippocampus, and that its content predicts subsequent performance improvements.
Neural sequences linked to salient behavioral events were prioritized for replay, with positive and negative behavioral outcomes having opposing effects on individual replay events.
All features of replay persisted despite complete bilateral hippocampal lesions. These findings demonstrate that procedural replay occurs independently of the hippocampus, indicating that replay-driven memory consolidation can operate through parallel, independent mechanisms."
Replay of procedural memory is independent of the hippocampus (open access, preprint published in 2024)
Fig. 1 Fig. 1: Learning and execution of the sequence learning task is dependent on the DLS.
Fig. 3 Replay of procedural neural activity in the striatum during sleep
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