LATE: A common cause of dementia you may have never heard of

Recommendable! Better LATE than  never! Don't be LATE!😄

"... Lewy body dementia, although Lewy body dementia (encompassing both dementia with Lewy bodies and Parkinson’s disease dementia) is the fourth most common cause. ...
It’s LATE, which stands for limbic-predominant age-related TDP-43 encephalopathy ...

In LATE, a protein called TDP-43 (which stands for transactive response DNA binding protein of 43 kDa) accumulates in brain cells. Once it accumulates, it injures and ultimately destroys the cells.

LATE generally damages many of the same areas affected by Alzheimer’s disease. These regions include

the amygdala, involved in emotional regulation

the hippocampus, involved in learning and memory

the temporal lobe, involved in words and their meanings

portions of the frontal lobes, involved with keeping information in mind and manipulating it. ..."

"... Because LATE was (and still is) often confused with Alzheimer’s disease, it is almost certain that when the main drugs that are FDA-approved to treat Alzheimer’s disease were evaluated, individuals with LATE were included in those studies. This means that there is every reason to believe that drugs like donepezil (brand name Aricept), rivastigmine (Exelon), memantine (Namenda), and galantamine will all be effective for individuals with dementia due to LATE. ..."

This is a very heroic assumption by this medical doctor author!

LATE: A common cause of dementia you’ve never heard of – Harvard Gazette LATE is now listed alongside the top three disorders that cause dementia in older individuals. It’s called LATE, but what exactly is it and why haven’t we heard of it before?

LATE: A common cause of dementia you’ve never heard of