Good news! Towards a pill/remedy for everything or the fountain of youth! Very soon you may not need a treadmill or jogging anymore (just kidding)! :-)
"Indeed, aged mice that received plasma from young or old mice that had exercised showed beneficial effects in their brains without hitting the treadmill. ... Plasma concentrations of glycosylphosphatidylinositol (GPI)–specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive impairments by altering signaling cascades downstream of GPI-anchored substrate cleavage. We thus identify a liver-to-brain axis by which blood factors can transfer the benefits of exercise in old age."
Boosting a liver protein may mimic the brain benefits of exercise | Science News Liver-made proteins that circulate in the blood improved memories, a mouse study suggests
Here is a link to the underlying paper:
Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
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