Good news! And it is tasty! What is on your menu today? Cancer is history (soon)!
"... While the widely consumed white button mushroom has been promoted as a nutraceutical with anticancer properties, its mechanism of action has not been understood. Now, a new study by researchers at City of Hope, one of the US’s largest and most advanced cancer research and treatment organizations, has uncovered how the popular fungus exerts its health effects. ..."
"... Supported by a $100 million gift from Panda Express Co-CEOs Andrew and Peggy Cherng, City of Hope’s Cherng Family Center for Integrative Oncology ...
In mouse models, researchers found that administration of white button mushroom extract significantly delayed the growth of tumors and extended the survival of mice. It also improved T cell immune response through the reduction of MDSC levels in animal models, meaning it improved the immune system’s ability to kill cancer. ..."
From the abstract:
"Background
In a previously reported Phase I trial, we observed therapy-associated declines in circulating myeloid-derived suppressor cells (MDSCs) with the administration of white button mushroom (WBM) tablets in prostate cancer (PCa) patients. These observations led us to hypothesise that WBM could mitigate PCa progression by suppressing MDSCs.
Methods
We performed bidirectional translational research to examine the immunomodulatory effects of WBM consumption in both syngeneic murine PCa models and patients with PCa participating in an ongoing randomised Phase II trial (NCT04519879).
Results
In murine models, WBM treatment significantly suppressed tumour growth with a reduction in both the number and function of MDSCs, which in turn promoted antitumour immune responses mediated by T cells and natural killer (NK) cells. In patients, after consumption of WBM tablets for 3 months, we observed a decline in circulating polymorphonuclear MDSCs (PMN-MDSCs), along with an increase in cytotoxic CD8+ T and NK cells. Furthermore, single immune cell profiling of peripheral blood from WBM-treated patients showed suppressed STAT3/IRF1 and TGFβ signalling in circulating PMN-MDSCs. Subclusters of PMN-MDSCs presented transcriptional profiles associated with responsiveness to fungi, neutrophil chemotaxis, leukocyte aggregation, and regulation of inflammatory response. Finally, in mouse models of PCa, we found that WBM consumption enhanced the anticancer activity of anti-PD-1 antibodies, indicating that WBM may be used as an adjuvant therapy with immune checkpoint inhibitors.
Conclusion
Our results from PCa murine models and patients provide mechanistic insights into the immunomodulatory effects of WBM and provide a scientific foundation for WBM as a nutraceutical intervention to delay or prevent PCa progression.
Highlights
White button mushroom (WBM) treatment resulted in a reduction in pro-tumoural MDSCs, notably polymorphonuclear MDSCs (PMN-MDSCs), along with activation of anti-tumoural T and NK cells.
Human single immune cell gene expression profiling shed light on the molecular alterations induced by WBM, specifically on PMN-MDSCs.
A proof-of-concept study combining WBM with PD-1 blockade in murine models revealed an additive effect on tumour regression and survival outcomes, highlighting the clinical relevance of WBM in cancer management."
City of Hope researchers discover why taking a mushroom supplement slows or prevents prostate cancer from getting worse (original news release) "The bidirectional research looks at both laboratory and human clinical trial data, finding that medicinal use of white button mushroom reduces the type of cells that weaken the immune system and allow prostate cancer to spread."
Fig. 8
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