"An antibody recovered from a survivor of the SARS epidemic in the early 2000s has revealed a potential vulnerability of the new coronavirus at the root of COVID-19 ... The structural mapping revealed a nearly identical site on both coronaviruses to which the antibody [anti-SARS-CoV antibody called CR3022] binds, suggesting a functionally important and vulnerable site for this family of coronaviruses. ... That high degree of similarity implies that the site has an important function that would be lost if it mutated significantly. Yet, the site’s function remains mysterious. ... The Wilson lab is known for its pioneering structural studies of antibodies bound to viruses including HIV and influenza. These studies have been used to inform designs of vaccines and antibody drugs, as well as other therapeutics. ... "
Clues to COVID-19 coronavirus’s vulnerability emerge from an antibody against SARS | Scripps Research
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