Good news! Cancer is history (soon)!
"... a previously overlooked population of immune cells called macrophages that patrol the edges of melanoma tumours, steadily engulfing cancer cells and slowing tumour growth. ...
“This is the first time anyone has captured a macrophage attacking and engulfing a live cancer cell in real time,” ..."
From the abstract:
"Macrophages in the skin reside in multiple distinct layers and perform various functions. Here, we show that CD169+ macrophages reside in the hypodermis and comprise the major skin myeloid cell population in the steady state.
In a syngeneic melanoma model, CD169+ macrophages encapsulate growing melanomas and directly suppress their growth.
CSF1R blockade depleted CD169+ macrophages in tumors and resulted in unrestrained growth.
This local containment of tumor growth in the skin was independent of CD169+ subcapsular sinus macrophages in the tumor-draining lymph node and did not require B or T cells.
Intravital imaging revealed engulfment and ingestion of live tumor cells by CD169+ macrophages.
This phagocytosis did not require the phosphatidylserine receptor MERTK. CD169+ macrophages are also enriched in the hypodermis in skin biopsies from healthy human skin and melanoma.
These data identify tissue-resident CD169+ macrophages as a potential cellular target to achieve innate immune containment and reinforce adaptive immune control of tumors."
A highly magnified view of melanoma tumours growing in the skin. CD169+ macrophages are shown in green and yellow forming a biological boundary wall to contain the tumours.
Fig. 2 Skin CD169+ macrophages suppress B16-F10 melanoma growth.
Fig. 4 Skin CD169+ macrophages ingest tumor cells.
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