Amazing stuff! Cancer is history (soon)!
Is this maybe another good reason to do daily tongue scraping?
"... In a new study, researchers have shown that mouth bacteria migrate through the gastrointestinal tract in certain types of cancer.1 The findings raise hope that the breakdown of these carefully sectioned-off compartments in the body could be an indicator of disease, leading to easier and quicker diagnostic tests for gastrointestinal cancers. ..."
"... In a study ... researchers report that by analyzing the make-up of oral microbes, they may be able to detect signals associated with gastric (stomach) and colorectal cancer. These findings could lead to the development of new, less-invasive screening tests for gastrointestinal cancers. ...
To conduct the study, the researchers recruited 507 volunteers to donate both oral and fecal samples, using a highly standardized collection process. The cohort included 129 healthy individuals; 215 people with metabolic disorders such as metabolic syndrome, hypertension, hyperlipidemia, and type 2 diabetes; 77 people with gastric cancer; and 86 people with colorectal cancer. For the volunteers with cancer, samples were collected before the start of any treatment. ...
The findings were more nuanced than a simple cancer-versus-healthy comparison. The MF index was significantly elevated in patients with gastric or colorectal cancer but not in people with metabolic disorders. After accounting for alcohol consumption, regular exercise, and BMI, the association remained robust for both gastric and colorectal cancers. ..."
From the highlights and abstract:
"Highlights
• Mouth and gut microbial compartmentalization is disrupted in gastrointestinal cancers
• Mouth-to-gut transmitted bacteria correlate with metabolic and inflammatory markers
• Oral-fecal transmission signatures enable cancer classification by oral microbiome alone
• Transmission-based classifier surpasses microbiota models and fecal occult blood testing
Summary
The human microbiome is spatially compartmentalized, yet oral bacteria can ectopically colonize distal sites such as the gut, potentially influencing disease.
By analyzing paired oral and fecal microbiomes from 507 participants across healthy controls and patients with metabolic disorders or gastrointestinal cancers, we established a quantitative mouth-to-feces (MF) index to measure MF microbial transmission.
The MF index revealed elevated mouth-to-gut transmission in cancer and a strong association with host metabolic and inflammatory indicators.
Using transmitted taxa, we developed a random forest classifier that accurately distinguished gastric/colorectal cancer from healthy controls across seven independent cohorts, even when trained solely on oral microbiome data.
When benchmarked against the conventional screening test, the MF-based model achieved markedly higher sensitivity than the fecal occult blood test.
These findings uncover disease-specific transmission signatures and highlight MF microbial profiling as a generalizable, non-invasive framework for gastrointestinal cancer diagnosis and risk stratification."
Graphical abstract
Figure 2. MF transmission index as an assessment of the mouth-gut microbiome axis
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