Key brain circuit regulating the entry into hibernation found at last

Amazing stuff!

Notice here the emphasis is on entry into hibernation not hibernation in general.

Notice Google Search was not able to find a news release regarding this discovery neither did the Whitehead Institute for Biomedical Research publish one although many of the authors of this study are affiliated with the WI. That is disappointing.

"... Now, in a preprint posted on bioRxiv, researchers studying hibernating Syrian hamsters have pinpointed for the first time a brain circuit that regulates an animal’s entry into hibernation. The results reveal a “key, really, in the network” and provide “more solid [evidence] than anything we had before” of an ancient hibernation circuit within the mammalian brain ..."

From the abstract:

"Evolution of seasonal hibernation has enabled mammals to survive harsh conditions by entering a state of prolonged hypometabolism and hypothermia with body temperatures as low as 0-4°C1–6.

Despite decades of physiological studies, the genetic tools to study hibernation have remained limited and the mechanisms that induce hibernation entry are still unknown.

Focusing on the brain, we map state-dependent neuronal activity across the hibernation cycle in Syrian hamsters and identify the hypothalamic anterior preoptic area (aPOA) as a key regulator of hibernation entry.

Single-nucleus RNA and chromatin profiling provided a map of neuronal populations present in the hamster POA and enabled the discovery and design of an enhancer AAV that selectively targets hibernation-associated aPOA subpopulations.

Using this genetic approach, we show that Samd3-positive aPOA glutamatergic neurons are necessary for entry into hibernation and that their activation is sufficient to induce a prolonged hypothermic state with associated nesting behavior.

Together, we identify the first neuronal population that controls entry into hibernation, opening new avenues for investigating and manipulating the metabolic and physiological mechanisms underlying this extreme state of “suspended animation” and its potential applications in aging and disease."

Key brain circuit regulating hibernation found at last | Science | AAAS

Preoptic Neurons that Control Entry into Hibernation

Fig. 2: Identification of anterior preoptic area activity as necessary for deep torpor entry.