Concerning, if not shocking!
"... “These data from multiple locations support the concept of silent atherosclerosis as a systemic, progressive disease process,” ..."
"Atherosclerosis, the process underlying most cardiovascular diseases, begins long before the first symptoms appear.
An international study shows that the disease can already be detected in apparently healthy young adults and is much more common than previously thought. ...
that 57.1% of the more than 16,000 participants included in the study had atherosclerotic plaques, despite having no symptoms or previous diagnosis of cardiovascular disease. ...
The data come from the first phase of REACT, one of the largest studies conducted to date to map the presence of silent atherosclerosis throughout adult life. ...
In the first phase, 16,808 people ages 18–70 were recruited in Denmark and Spain. None of the participants had a known history of atherosclerotic cardiovascular disease. Each participant underwent advanced imaging to detect atherosclerotic plaques in the carotid, femoral and coronary arteries. Cardiovascular risk factors, blood biomarkers, samples for omics studies and retinal images were also analyzed, generating one of the most comprehensive databases on atherosclerosis developed to date.
The results show that the disease is already present in very young adults. Approximately 1 in 13 people ages 18–29 had atherosclerosis in at least one artery. This proportion increased progressively with age, reaching 9 in 10 people ages 60–70. ...
The study also reveals important differences between women and men.
In men, prevalence began to increase at younger ages, with an atherosclerotic profile five–10 years ahead of that observed in women.
In women, the sharpest increase was observed between the ages of 40 and 60, a period that broadly coincides with the menopausal transition. ...
Another of the study's most relevant findings is that the conventional methods currently used to estimate cardiovascular risk, including risk scores such as SCORE2, identify only a small proportion of people who already have silent atherosclerosis. ..."
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