Friday, August 21, 2026

Engineers connect bacteria to create living transistors

Amazing stuff! Are we getting closer to artificial biological intelligence? You bet!

The human brain is a lot more energy efficient than machine learning & artificial intelligence. The human brain does not need a voracious water and energy consuming data center!

"MIT researchers have engineered bacteria that can function as transistors, allowing the team to create living “circuit boards” that can be printed onto a growth medium in a Petri dish. ...

The research team designed two different transistors, along with three bacterial strains that relay information between the transistors, giving them the building blocks they need to design nearly any type of circuit. In a new study, they used these cells to create circuits that can add two or three inputs, or send one input to a specific location in the circuit. ..."

From the abstract:
"The multicellular forms and functions seen in biology are controlled by cellular communication and collective computation.
Reprogramming natural systems is difficult because they comprise many signaling molecules connecting a web of regulatory networks within cells.
Here we apply principles from pass transistor logic (PTL) to design bacteria that can be easily reconfigured to perform computations on a solid surface. Strains of Pantoea agglomerans were built to encode two transistors (N-type and P-type) whose inputs and outputs are small molecules. They are connected by three relay strains that convert molecular diffusion to unidirectional flow.
To build circuits, an acoustic liquid handler prints patterns of these five strains on a surface.
By changing the pattern, not requiring any genetic changes, different operations are implemented, including multi-input multioutput logic, demultiplexor, half-adder and full-adder.
This work demonstrates that only five cell types, each encoding a simple operation, can be scaled to create complex computational operations."

MIT engineers connect bacteria to create living transistors | MIT News | Massachusetts Institute of Technology "By wiring together colonies of these bacteria, the researchers built circuits that can perform complicated calculations."





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