Could this be more proof that a modified coronavirus (SARS-CoV-2) or perhaps a biological weapon was leaked from the Wuhan Institute of Virology in China. The Institute is believed to be a dual use research institute. What did Anthony Fauci know about this?
Or is this result just due to the super intensive research into the cause of Covid-19?
Or was this expected to happen due to the typically weakened immune system of an individual after Covid-19 infection?
Such reactivations of dormant viruses is definitely something to be aware of!
"As if an infection with SARS-CoV-2 wasn’t enough for a body to handle, the coronavirus reawakens a variety of other, dormant viruses in some people. A large new study delving into this phenomenon shows this virus reactivation is complex and the health impact murky, but it could worsen symptoms of COVID-19 and increase a person’s risk of Long Covid.
The study looked at tissues samples and medical reports from more than 1000 COVID-19 patients early in the pandemic. “Nearly half of people … had a virus that they were already carrying wake up,” said neuroimmunologist and co-author Esther Melamed. “This happens [even] in people whose immune systems are otherwise normal.”
The work has impressed some SARS-CoV-2 researchers. “The scale of the endeavor and the range of human viruses they’ve looked at” makes this the most comprehensive data set yet on viral reactivation in COVID-19 ..."
"Early in the COVID-19 pandemic, scientists noticed that a SARS-CoV-2 infection can “wake up” other, dormant viruses already present in the body.
A study out today in Nature extends those and subsequent observations, documenting viral reactivation for a cohort of more than 1000 patients hospitalized with COVID-19 before mid-2021. ...
The findings, which were partially described in a preprint in late 2024, include data on viruses previously overlooked in COVID-19 patients, he adds. ..."
From the abstract:
"Chronic viral infections are ubiquitous in humans, with individuals carrying multiple viruses that can reactivate during physiological stress, including severe illness.
Notably, SARS-CoV-2 infection has been shown to reactivate chronic viruses such as Epstein–Barr virus and cytomegalovirus, yet the full extent, temporal dynamics and immunological impact of viral reactivation in COVID-19 remain incompletely understood.
Here, leveraging multi-omic longitudinal data from 1,154 hospitalized patients with COVID-19 from the Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study, we reveal significant reactivation of Herpesviridae and Anelloviridae during acute COVID-19, with distinct temporal dynamics for different viruses, and demonstrate that reactivation correlates with disease severity, host immune effects and clinical outcomes.
Although our results do not establish causation between virus reactivation and clinical outcomes, we highlight the prevalence of chronic viral reactivation during acute COVID-19 and long COVID.
Our findings challenge the prevailing view that chronic viral reactivation is primarily a consequence of immunosuppression, demonstrating that reactivations occur frequently in immunocompetent individuals during severe illness and in association with increased systemic inflammation.
Additionally, we demonstrate persistence of viral reactivation in convalescence, and report an association of Anelloviridae with long COVID.
This study provides immune, transcriptomic and metabolomic signatures of viral reactivation that could inform future strategies to prognosticate and treat acute COVID-19 and long COVID."
COVID-19 can wake up dormant viruses in the body, large study confirms "Virus reactivations by SARS-CoV-2 could worsen initial symptoms and increase risk of Long Covid"
Virus reactivation in acute and long COVID-19 (open access)
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19 (preprint from 2024, open access)
Fig. 1: The transcriptionally active human virome of the blood, upper airway and lungs in patients who were hospitalized for COVID-19.
Fig. 3: Antibody response, proteomics, and circulating cellular immunophenotyping validates chronic viral reactivation in COVID-19.
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