This seems to be an interesting new drug!
"Early results for a pill which mimics some of the chemistry of exercise have been positive, announced the company making the pill, Enveda. The trial was conducted in 88 non-obese people, with no adverse effects and none of the side effects often seen in GLP-1s, such as nausea or vomiting.
The pill mimics the enzyme lactate phenylalanine to make people more sensitive to leptin — the hormone which limits appetite — thereby helping to maintain weight loss rather than yo-yoing. The upcoming phase II trial will involve people who have come off GLP-1s to see if the drug can help them to maintain their weight loss."
"Exceptional safety was observed across 88 healthy volunteers. Phase 2 plans to test whether ENV-308 can help people maintain their weight after stopping GLP-1s.
- ENV-308 is the first drug in human trials designed to mimic Lac-Phe, a pseudo dipeptide hormone released by the body in response to high-intensity exercise.
- In its first clinical trial, ENV-308 was extremely well tolerated across 88 healthy volunteers, including for gastrointestinal safety – the most common side effect that leads to people stopping GLP-1 medicines.
- The trial showed ENV-308 reduced circulating leptin, an exploratory signal that the drug reaches biology relevant to metabolic disease.
- In animal studies, ENV-308 preserved lean muscle during weight loss and prevented weight regain after weight-loss therapy was stopped.
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Enveda Reports Positive Phase 1 Results for ENV-308, the First Pill Designed From the Chemistry of Exercise (original news release)
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