Good news! Cancer is history (soon)! This seems to be a strong trend to develop diagnostics to detect cancer long before cancer diagnosis.
"Genetic material shed by tumors can be detected in the bloodstream three years prior to cancer diagnosis, according to a study led by investigators at Johns Hopkins University. ...
Key Takeaways
- ... investigators discover genetic material shed by cancerous tumors in blood samples years before patients showed any clinical signs or symptoms.
- A multicancer early detection (MCED) laboratory test was used to evaluate plasma samples from a large NIH-funded study to investigate risk factors for cardiovascular diseases.
- MCED tests have the potential to find cancers sooner, leading to better outcomes with treatment.
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From the abstract:
"To explore how early can cancers be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities (ARIC) study, including 26 participants diagnosed with cancer and 26 matched controls.
At the index time point, eight of these 52 participants scored positively with a multicancer early detection (MCED) test. All eight participants were diagnosed with cancer within 4 months after blood collection.
In six of these 8 participants, we were able to assess an earlier plasma sample collected 3.1 to 3.5 years prior to clinical diagnosis.
In four of these six participants, the same mutations detected by the MCED test could be identified, but at 8.6 to 79-fold lower mutant allele fractions.
These results demonstrate that it is possible to detect circulating tumor DNA more than three years prior to clinical diagnosis, and provide benchmark sensitivities required for this purpose."
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