Good news! Cancer is history (soon)! God have mercy on this 23-year old woman!
This news release by Mayo Clinic sucks in so far as it does not contain the words woman/women at all although a ovarian cancer is sex specific and no transgender female was ever reported to have suffered from it as I believe! Only beginning in the fourth paragraph does the female journalist mention the pronoun "she" for the first time. This is really appalling!
"... But in the fallopian tube cells collected from the patient with HBOC syndrome and Li-Fraumeni syndrome, the scientists saw something they had never seen before. Instead of the two types of epithelial cells, the secretory cells vastly outnumbered the multiciliated cells across the fallopian tube. They also found that secretory cells were driving chronic inflammation — an established contributor to cancer development. ..."
From the results (the research articles does not appear to contain an abstract):
"Results
A 23-year-old woman presented to Mayo Clinic with a palpable right breast mass and intermittent unilateral nipple discharge.
Biopsy confirmed grade 2 invasive ductal carcinoma.
Magnetic resonance imaging and positron emission tomography-computed tomography revealed clinical stage IB disease along with a left renal mass and ovarian cyst (Fig 1A).
Genetic testing identified germline mutations: a likely pathogenic variant in TP53 (c.96+1G>C) affecting a splice donor site, suspected to disrupt RNA splicing and impair protein function, and a pathogenic BRCA2 variant (c.6275_6276del) causing a premature stop codon and loss of protein function (Fig 1B).
The patient underwent bilateral nipple-sparing mastectomy because of her elevated risk of radiation-associated malignancies (Fig 1C).
Renal biopsy revealed grade 3 papillary renal cell carcinoma (RCC), and she then underwent robotic-assisted partial nephrectomy.
Pathology confirmed TFE3-rearranged RCC with negative surgical margins and lymph nodes (Fig 1D).
After counseling for increased risk of therapy-related myeloid neoplasms, the patient decided to proceed with chemotherapy for breast cancer and completed 12 weeks of paclitaxel/carboplatin neoadjuvant therapy."
Mayo Clinic researchers capture first signs of ovarian cancer risk (appears to be the original news release)
Credits: Researchers capture first signs of ovarian cancer risk
Fig 1. Identification and histologic characterization of multiple tumors in a gTP53/BRCA2-DH patient. [This is an impressive looking chart!]
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