Wednesday, June 18, 2025

New vaccine shows promise against pancreatic cancer in preclinical studies

Good news! Cancer is history soon! This research still seems to be in early stage, the details seem sketchy and no published results.

"... The pioneering work from ... researchers targets pancreatic ductal adenocarcinoma (PDAC), the most common cancer that plagues the organ. While pancreatic cancer may not be as prevalent as breast, prostate, lung and colorectal cancers, it's particularly insidious. It commonly remains undetected until it metastasizes, and then treatment is simply to buy more time. The five-year survival rate for this cancer is just 13.3%. ...

The treatment centers around targeting the most common mutations seen in PDAC tumor cells, using nanoparticles loaded with antigens that trigger the immune system to attack and destroy the cancer growth. In preclinical trials, which generally test novel treatments on isolated cell cultures or animals, the vaccine eliminated the cancer in more than half of the targets. ...

Treatment would involve three injections of the anti-cancer nanoparticles, with a complementary immune checkpoint inhibitor to boost the body's tumor-fighting capabilities, limiting the ability of tumors to evade immune cell detection. ...

The institution is yet to publish new research on the vaccine, but is expected to release data once preclinical trials have concluded. ..."

New vaccine shows promise against pancreatic cancer

Pancreatic cancer vaccines eliminate disease in preclinical studies "Case Western Reserve University researchers combat deadly cancer with therapeutic vaccines"

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