Amazing stuff! As they say Mens sana in corpore sano!
"As we age, our muscles tend to shrink and get weaker. This loss of mass and strength is a major reason for disability in older people. ... a key player in muscle health: its own internal clock.
... body’s central timekeeper or circadian rhythm, we actually have many internal clocks. Different parts of our bodies have their own timekeepers, and the coordination of these peripheral clocks with the central one in the brain appears to be key to maintaining health. Mice lacking the molecular timekeeping protein Bmal1 in either their brains or their muscles exhibited premature muscle aging, found the new study. Only restoring it in both places allowed the mice’s muscles to stay fit. A study of skin, concurrently published in Cell Stem Cell , came to a similar conclusion. In both studies, the researchers found that the peripheral clock played an important role in interpreting the brain’s timing signals to optimize tissue functioning.
“It is fascinating to see how synchronization between the brain and peripheral circadian clocks plays a critical role in skin and muscle health, while peripheral clocks alone are autonomous in carrying out the most basic tissue functions,” ..."
From the editor's summary and abstract:
"Editor’s summary
Mice lacking the circadian clock component Bmal1 show not only disrupted rhythms but also premature aging and muscle wasting. To explore the specific roles of the central brain clock and the peripheral clock in muscle, Kumar et al. restored clock function by targeted expression of Bmal1 in the brain, skeletal muscle, or both. Restoration of both clocks was needed to substantially inhibit premature aging and muscle dysfunction. The muscle clock alone did not restore rhythmicity but acted to filter signals from the brain clock to achieve proper muscle function. Time-restricted feeding, a behavioral timing cue, could partially substitute for loss of the central clock. Such insights should enhance our understanding of the roles of circadian disruption in aging and provide potential strategies to protect muscle function in aging individuals. ...
Abstract
A molecular clock network is crucial for daily physiology and maintaining organismal health. We examined the interactions and importance of intratissue clock networks in muscle tissue maintenance. In arrhythmic mice showing premature aging, we created a basic clock module involving a central and a peripheral (muscle) clock. Reconstituting the brain-muscle clock network is sufficient to preserve fundamental daily homeostatic functions and prevent premature muscle aging. However, achieving whole muscle physiology requires contributions from other peripheral clocks. Mechanistically, the muscle peripheral clock acts as a gatekeeper, selectively suppressing detrimental signals from the central clock while integrating important muscle homeostatic functions. Our research reveals the interplay between the central and peripheral clocks in daily muscle function and underscores the impact of eating patterns on these interactions."
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