Good news!
Note it seems to have quite a different effect on male compared with female mice.
"New research has found that reducing the intake of a single amino acid, isoleucine, by two-thirds, improved the lifespan, weight, and health of middle-aged mice without requiring a drop in calorie intake. ...
That one component is isoleucine, one of nine essential amino acids. Data from an earlier study into the health of Wisconsinites found that those with a higher BMI tended to consume more isoleucine, which is plentiful in foods including eggs, dairy, soy protein and many meats.
To further investigate the effects of isoleucine on health, the researchers placed male and female genetically diverse mice on one of three amino-acid-defined diets. The control diet contained all 20 common amino acids, reflecting a natural chow where 21% of calories are derived from protein. ...
“Very quickly, we saw the mice on the reduced isoleucine diet lose adiposity – their bodies got leaner, they lost fat,” ... In comparison, the mice eating the low-amino-acid diet initially got leaner but regained weight and fat.
The researchers found that mice on the reduced-isoleucine diet lived longer compared to controls; males, on average, 33% longer and females 7%. ..."From the highlights and abstract:
"Highlights
• Isoleucine restriction (IleR) improves metabolic health in both sexes
• IleR reprograms hepatic metabolism in a sex- and age-dependent manner
• IleR reduces frailty and increases lifespan, with stronger effects on male lifespan
• Amino acid restriction begun at 6 months extends healthspan but not lifespan
Summary
Low-protein diets promote health and longevity in diverse species. Restriction of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of these benefits in young C57BL/6J mice. Restriction of dietary isoleucine (IleR) is sufficient to promote metabolic health and is required for many benefits of a low-protein diet in C57BL/6J males. Here, we test the hypothesis that IleR will promote healthy aging in genetically heterogeneous adult UM-HET3 mice. We find that IleR improves metabolic health in young and old HET3 mice, promoting leanness and glycemic control in both sexes, and reprograms hepatic metabolism in a sex-specific manner. IleR reduces frailty and extends the lifespan of male and female mice, but to a greater degree in males. Our results demonstrate that IleR increases healthspan and longevity in genetically diverse mice and suggests that IleR, or pharmaceuticals that mimic this effect, may have potential as a geroprotective intervention."
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice (no public access)
Graphical abstract
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