Sunday, December 24, 2023

Cryo-Electron Microscopy at Just One-Tenth the Cost

Good news!

"Over the past decade, cryo-electron microscopy (cryoEM) has emerged as a powerful tool for determining the detailed structures of complex molecules. Now, a new design from researchers ... could slash the cost of cryoEM by 90 percent. This could bring structural studies in biology and material science within reach of researchers who must currently send their samples out to regional centers or colleagues at wealthier organizations. ...
Nature Methods named cryoEM its “2015 Method of the Year.’’ The 2017 Nobel Prize in Chemistry ... CryoEM applications have exploded in the years since. ..."

"... Current state-of-the-art microscopes now cost several million pounds, precluding many researchers and institutes from using the beneficial approach and ultimately slowing down progress towards molecular discoveries. ..."

Cryo-Electron Microscopy at Just One-Tenth the Cost - IEEE Spectrum New design can make complex molecular imaging available to any lab

Low energy cryo-EM to widen accessibility for fast and accurate structure determination



This diagram of the cryoEM microscope highlights the components that the MRC-LMB focused on improving

Structures solved by 100 keV electron microscope


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