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"... A central question in diabetes research is why cells of the pancreas, known as beta cells, initially over-secrete insulin. ... The team found that in beta cells from obese, pre-diabetic animals, a protein known as Cyclophilin D, or CypD, induced a phenomenon known as “proton leak,” and that this leak promoted insulin secretion in the absence of elevated glucose. ..."
Researchers discover process that may explain how Type 2 diabetes develops | UCLA
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