Recommendable! Seems to be an interesting new approach!
"Here, we identify a single protein (LiaX) that senses antimicrobial molecules and regulates changes in CM [cell membrane] phospholipid architecture. We show that LiaX-mediated modulation of antibiotic and AMP resistance affects virulence during infection caused by a recalcitrant hospital pathogen. Targeting this response in multidrug-resistant organisms may be a therapeutic intervention to restore susceptibility to cell envelope-targeting antibiotics and increase the ability of the immune system to clear pathogens"
Scientists hope to fight antibiotic-resistant bacteria by targeting their ‘alarm proteins’ | Science | AAAS: Future treatments could hijack the microbes’ communication systems
Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis
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