Friday, September 19, 2025

Wyss Institute received funding to develop first Human Organ Chip model for heavy menstrual bleeding

Good news! It is actually surprising and shocking to learn that: (1) so many women (about 1 in 3 of reproductive age) suffer from heavy menstrual bleeding and (2) that at the end of the first quarter of the 21st century it appears so little can be done to treat it.

Feminists would argue the situation is largely due to the fact that medicine and medical research was dominated by men for centuries and that women bear the heavy menstrual bleeding as a personal, intimate matter.

"The Wyss will use its pioneering Organ Chip technology to create the first human model of heavy menstrual bleeding (HMB), a condition that affects one in three women of reproductive age yet remains underdiagnosed, undertreated, and poorly understood.

The new Organ Chip model will allow researchers to uncover the causal factors and early biomarkers of HMB progression and identify potential non-hormonal therapeutics by combining multi-omics analysis with artificial intelligence (AI)-driven computational approaches. This breakthrough aims to shorten the time women wait for effective treatment from an average of five years to just five months. ...

HMB is more common than asthma or diabetes, yet it has been largely ignored by healthcare systems worldwide. Its consequences are profound. As outlined on Wellcome Leap’s website:

  • Every minute in the U.S., a woman requires a blood transfusion due to menstruation.
  • Up to 50% of reproductive-aged women globally (950 million people) are iron deficient, with chronic HMB expected to be a major contributor.
  • Women with HMB miss an average of 3.6 working weeks annually, costing the U.S. economy more than $94 billion each year.
  • Mental health impacts are significant, with women suffering from HMB experiencing rates of anxiety and depression three times higher than the general female population.
..."

Wyss Institute receives Wellcome Leap funding to develop first Human Organ Chip model for heavy menstrual bleeding "Breakthrough aims to shorten the time women wait for effective treatment from an average of five years to just five months"

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