The “unknome”: a database of human genes we know almost nothing about

This is a new paper to be published by PLOS Biology, but it is still under embargo until 8/1/2023. Sounds promising!

"Sharpening the focus on unknown proteins to accelerate research"

From the abstract:
"Researchers from the United Kingdom hope that a new, publicly available database they have created will shrink, not grow, over time. That’s because it is a compendium of the thousands of understudied proteins encoded by genes in the human genome, whose existence is known but whose functions are mostly not. The database, dubbed the “unknome” ... Their own investigations of a subset of proteins in the database reveal that a majority contribute to important cellular functions, including development and resilience to stress. ..."

Here is the project's website: The Unknome project