Now that seems to be a bit counterintuitive! 😊 Cancer is history (soon)!
A sweet tooth is a cancer foe? How sweet is that!
"Researchers have made several chemotherapies more effective against pancreatic cancer in mice by raising their blood sugar levels — a process called ‘forced hyperglycaemia’. Depriving pancreatic cancer of nutrients such as glucose triggers a stress response that makes the cancer more resistant to chemotherapy. When pancreatic cancer is flooded with glucose, it lowers its defences. ..."
From the abstract:
"Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, as chemotherapy remains the best available systemic treatment. However, the discovery of safe and available adjuncts to enhance chemotherapeutic efficacy can still improve survival outcomes. We show that a hyperglycemic state substantially enhances the efficacy of conventional single- and multi-agent chemotherapy regimens against PDAC. Molecular analyses of tumors exposed to high glucose levels reveal that the expression of GCLC (glutamate-cysteine ligase catalytic subunit), a key component of glutathione biosynthesis, is diminished, which in turn augments oxidative anti-tumor damage by chemotherapy. Inhibition of GCLC phenocopies the suppressive effect of forced hyperglycemia in mouse models of PDAC, while rescuing this pathway mitigates anti-tumor effects observed with chemotherapy and high glucose."
Fig. 2: High-glucose diet in mice improves conventional chemotherapy response.
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