Thursday, July 06, 2023

Human testing for potential new TB treatment to tackle the ongoing TB epidemic in Africa. First in nearly six decades!

Good news! Bravo Bill and Melinda Gates Foundation!

"... using nanoparticles to activate the human immune system to destroy TB bacteria. This helps control the rising antibiotic-resistant strains of TB. ..."

"A new treatment for tuberculosis delivers a ‘kick and punch’ effect: nanoparticles ramp up the immune system and a drug molecule attacks the bacterium that causes illness. It has been nearly six decades since the last tuberculosis intervention came onto the market. ...
Two major funders — the Bill and Melinda Gates Foundation and Wellcome — have invested US$550 million in a promising vaccine for tuberculosis. ... The bacterium can hide in the body for years before triggering an active infection that shows symptoms. The vaccine candidate, M72/AS01E, aims to tackle these latent infections. If successful, it would be the first new tuberculosis vaccine on the market in more than a century. ..."

"... Tuberculosis, caused by Mycobacterium tuberculosis, is one of the world’s biggest epidemics, claiming 1.6 million lives each year. The burden is particularly high in low- and middle-income countries. ..."

Human testing for potential new TB treatment, first in nearly six decades Activating patients’ own immune systems to end TB infection, without antibiotics

Promising tuberculosis vaccine gets US$550-million shot in the arm The candidate is moving to long-awaited phase III trials — if successful, it would be the first new jab against the disease in more than 100 years.

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