Anti-ageing protein klotho injection boosts monkeys’ memories

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"Injecting ageing monkeys with a ‘longevity factor’ protein can improve their cognitive function, a study reveals. ... could lead to new treatments for neurodegenerative diseases.

It is the first time that restoring levels of klotho — a naturally occurring protein that declines in our bodies with age — has been shown to improve cognition in a primate. Previous research on mice had shown that injections of klotho can extend the animals’ lives and increases synaptic plasticity — the capacity to control communication between neurons, at junctions called synapses. ..."

From the abstract:

"Cognitive dysfunction in aging is a major biomedical challenge. Whether treatment with klotho, a longevity factor, could enhance cognition in human-relevant models such as in nonhuman primates is unknown and represents a major knowledge gap in the path to therapeutics. We validated the rhesus form of the klotho protein in mice showing it increased synaptic plasticity and cognition. We then found that a single administration of low-dose, but not high-dose, klotho enhanced memory in aged nonhuman primates. Systemic low-dose klotho treatment may prove therapeutic in aging humans."

Anti-ageing protein injection boosts monkeys’ memories First primate studies to show cognitive benefits of the protein klotho could be a step towards clinical applications.

Longevity factor klotho enhances cognition in aged nonhuman primates (open access)