Accurate Protein Production Promotes Longevity

Very recommendable! Possibly a breakthrough! Discovering the fountain of youth an age old quest!

"Highlights

• Evolutionarily selected arginine in RPS23 is present only in hyperthermophilic archaea

• RPS23 K60R mutation in flies leads to improved accuracy of protein synthesis with age

• Yeast, worm, and fly RPS23 K60R mutants are longer-lived, healthier, and heat resistant

• Anti-aging drugs, rapamycin, torin1, and trametinib, increase translation accuracy"

Entire abstract:

"Loss of proteostasis is a fundamental process driving aging. Proteostasis is affected by the accuracy of translation, yet the physiological consequence of having fewer protein synthesis errors during multi-cellular organismal aging is poorly understood. Our phylogenetic analysis of RPS23, a key protein in the ribosomal decoding center, uncovered a lysine residue almost universally conserved across all domains of life, which is replaced by an arginine in a small number of hyperthermophilic archaea. When introduced into eukaryotic RPS23 homologs, this mutation leads to accurate translation, as well as heat shock resistance and longer life, in yeast, worms, and flies. Furthermore, we show that anti-aging drugs such as rapamycin, Torin1, and trametinib reduce translation errors, and that rapamycin extends further organismal longevity in RPS23 hyperaccuracy mutants. This implies a unified mode of action for diverse pharmacological anti-aging therapies. These findings pave the way for identifying novel translation accuracy interventions to improve aging."

Accurate Protein Production Promotes Longevity | The Scientist Magazine® Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.

Increased fidelity of protein synthesis extends lifespan (no public access) ribosometranslation; protein synthesis; aging; mTOR; translation fidelity; translation accuracy; archaeaproteostasis; RPS23