Researchers devise more efficient, enduring CAR gene therapy to combat HIV

Good news!

"... This new approach to CAR T gene therapy — a type of immunotherapy that involves genetically engineering the body’s own blood-forming stem cells to create HIV-fighting T cells — has the potential to not only destroy HIV-infected cells but to create “memory cells” that could provide lifelong protection from infection with the virus that causes AIDS. ..."

"... Here we report a novel CAR-based approach targeting HIV infection using the genetic modification of blood forming hematopoietic stem cells (HSCs). This novel CAR approach uses a modified HIV receptor molecule (the primary HIV receptor CD4) as well as anti-HIV agents to modify HSCs to allow them to develop into cells that are protected from HIV infection and target HIV infected cells for the life of the individual. ..."

Researchers devise more efficient, enduring CAR gene therapy to combat HIV | UCLA

Here is the link to the underlying research paper:

Robust CAR-T memory formation and function via hematopoietic stem cell delivery