Good news!
"... Extracellular vesicles (EVs) — nanometer sized messengers that travel between cells to deliver cues and cargo — are promising tools for the next generation of therapies for everything from autoimmune and neurodegenerative diseases to cancer and tissue injury. ... even though these vesicles are only a hundred and fifty nanometers in diameter, they contain almost 2,000 different proteins ... Now, researchers ... have unraveled potential mechanisms behind the healing power of EVs and demonstrated their capacity to not only revive cells after a heart attack but keep cells functioning while deprived of oxygen during a heart attack. The researchers demonstrated this functionality in human tissue using a heart-on-a-chip with embedded sensors that continuously tracked the contractions of the tissue. "
"... This study characterized the protein cargo of human vascular endothelial EVs (EEVs) to identify lead cardioactive proteins and assessed the effect of EEVs on human laminar cardiac tissues (hlCTs) exposed to IRI [ischemia-reperfusion injuryor reoxygenation injury, happens when blood supply returns to tissue after a period of lack of oxygen]. We mapped the protein content of human vascular EEVs and identified proteins that were previously associated with cellular metabolism, redox state, and calcium handling, among other processes. ... Moreover, we found that EEVs increased the respiratory capacity of normoxic cardiomyocytes. ..."
Here is the link to the underlying research paper:
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